3-METHYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE

Base Information

• Chemical Name: 3-METHYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
• CAS No.: 31883-79-1
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.203
• Hs Code.: 2933790090
• Mol file: 31883-79-1.mol

Synonyms:3-methyl-2-oxo-1,2,3,4-tetrahydroquinoline;3-METHYL-1,2,3,4-TETRAHYDROQUINOLIN-2-ONE;

Chemical Property of 3-METHYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE

Chemical Property:

• Melting Point: 130 °C
• Boiling Point: 325.1±31.0 °C(Predicted)
• PKA: 14.80±0.40(Predicted)
• PSA: 32.59000
• Density: 1.083±0.06 g/cm3(Predicted)
• LogP: 1.90240

Purity/Quality:

97% ^*data from raw suppliers

3-Methyl-3,4-dihydroquinolin-2(1H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE

There total 39 articles about 3-METHYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.27%

1-[(4-methoxyphenyl)methyl]-3-methyl-3,4-dihydroquinolin-2-one (792122-85-1) → 3-methyl-3,4-dihydroquinolin-2(1H)-one (31883-79-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 65 ℃; for 12h;

Reference yield: 77.0%

methyl 2-(2-nitrobenzyl)propanoate (60031-27-8) → 3-methyl-3,4-dihydroquinolin-2(1H)-one (31883-79-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tert-butyl alcohol; at 50 ℃; for 72h;

DOI:10.1021/ol402398s

Reference yield: 75.0%

2-iodophenylamine (615-43-0) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → 3-methyl-3,4-dihydroquinolin-2(1H)-one (31883-79-1)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In dimethyl sulfoxide; at 120 ℃;

DOI:10.1016/j.tet.2009.01.027

upstream raw materials:

3,4-dihydro-2(1H)-quinolone

methyl iodide

2,3-dihydro-2-methyl-1H-inden-1-one

2-methylindanone oxime

Downstream raw materials:

3,3-dimethyl-3,4-dihydroquinolin-2(1H)-one

2-chloro-3-methyl-quinoline

3-methylcarbostyril

3-Chloro-3-methyl-3,4-dihydro-1H-quinolin-2-one