2-Indolizinecarboxylic acid, 5,6,7,8-tetrahydro-

Base Information

Chemical Name:2-Indolizinecarboxylic acid, 5,6,7,8-tetrahydro-
CAS No.:16959-59-4
Molecular Formula:C₉H₁₁NO₂
Molecular Weight:165.192
Hs Code.:
Mol file:16959-59-4.mol

Synonyms:5,6,7,8-Tetrahydroindolizin-2-carbonsaeure;5,6,7,8-tetrahydro-indolizine-2-carboxylic acid;5,6,7,8-tetrahydroindolizin-2-carboxylic acid;

Suppliers and Price of 2-Indolizinecarboxylic acid, 5,6,7,8-tetrahydro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5,6,7,8-tetrahydroindolizine-2-carboxylicacid
50mg
$ 240.00

Crysdot
5,6,7,8-Tetrahydroindolizine-2-carboxylicacid 97%
1g
$ 804.00

Chemenu
5,6,7,8-Tetrahydroindolizine-2-carboxylicacid 95%+
1g
$ 1517.00

Alichem
5,6,7,8-Tetrahydroindolizine-2-carboxylicacid
1g
$ 901.32

AK Scientific
5,6,7,8-Tetrahydroindolizine-2-carboxylicacid
10g
$ 4492.00

Total 3 raw suppliers

Chemical Property of 2-Indolizinecarboxylic acid, 5,6,7,8-tetrahydro-

Chemical Property:

Melting Point:131 - 134 °C
Boiling Point:370.6±30.0 °C(Predicted)
PSA：42.23000
Density:1.31±0.1 g/cm3(Predicted)
LogP:1.52260

Purity/Quality:

97% ^*data from raw suppliers

5,6,7,8-tetrahydroindolizine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Indolizinecarboxylic acid, 5,6,7,8-tetrahydro-

There total 7 articles about 2-Indolizinecarboxylic acid, 5,6,7,8-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 3189-48-8
indolizine-2-carboxylic acid

: 16959-59-4
5,6,7,8-tetrahydroindolizine-2-carboxylic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 80 ℃; for 6h; under 12001.2 Torr;

Reference yield:

: 87281-44-5
methyl 5,6,7,8-tetrahydroindolizine-2-carboxylate

: 16959-59-4
5,6,7,8-tetrahydroindolizine-2-carboxylic acid

Guidance literature:: methyl 5,6,7,8-tetrahydroindolizine-2-carboxylate; With potassium hydroxide; In tetrahydrofuran; methanol; water; for 2h; Reflux;

With hydrogenchloride; In water; for 0.5h;
DOI:10.1016/j.ejmech.2019.111618

Reference yield:

: 1121-60-4
pyridine-2-carbaldehyde

: 16959-59-4
5,6,7,8-tetrahydroindolizine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / 1,4-dioxane; water / 24 h / 20 °C

2.1: Heating

3.1: Heating

4.1: palladium 10% on activated carbon; hydrogen / methanol / 2660.18 Torr

5.1: potassium hydroxide / water; tetrahydrofuran; methanol / 2 h / Reflux

5.2: 0.5 h

With 1,4-diaza-bicyclo[2.2.2]octane; palladium 10% on activated carbon; hydrogen; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1016/j.ejmech.2019.111618