Methyl 2-[hydroxy(pyridin-2-yl)methyl]prop-2-enoate

Base Information

• Chemical Name: Methyl 2-[hydroxy(pyridin-2-yl)methyl]prop-2-enoate
• CAS No.: 118488-74-7
• Molecular Formula: C10H11NO3
• Molecular Weight: 193.202
• DSSTox Substance ID: DTXSID101234027
• Nikkaji Number: J1.319.245F
• Mol file: 118488-74-7.mol

Synonyms:methyl 2-[hydroxy(pyridin-2-yl)methyl]prop-2-enoate;118488-74-7;Methyl 2-(Hydroxy(pyridin-2-yl)methyl)acrylate;SCHEMBL14915338;SRSGIDZSIQOOMC-UHFFFAOYSA-N;DTXSID101234027;AKOS000209472;AKOS016905167;CS-0232795;EN300-128751;2-(2-Pyridylhydroxymethyl)acrylic acid methyl ester;methyl2-[hydroxy(pyridin-2-yl)methyl]prop-2-enoate;Methyl beta-hydroxy-alpha-methylene-2-pyridinepropanoate;Z320967362

Chemical Property of Methyl 2-[hydroxy(pyridin-2-yl)methyl]prop-2-enoate

Chemical Property:

• PSA: 59.42000
• LogP: 0.84420
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 193.07389321
• Heavy Atom Count: 14
• Complexity: 227

Purity/Quality:

98%min ^*data from raw suppliers

Methyl2-[Hydroxy(pyridin-2-yl)methyl]prop-2-enoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(=C)C(C1=CC=CC=N1)O

Technology Process of Methyl 2-[hydroxy(pyridin-2-yl)methyl]prop-2-enoate

There total 3 articles about Methyl 2-[hydroxy(pyridin-2-yl)methyl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyridine-2-carbaldehyde (1121-60-4) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 2-(hydroxy-pyridin-2-yl-methyl)-acrylic acid methyl ester (118488-74-7)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In 1,4-dioxane; water; at 20 ℃; for 1h;

DOI:10.1021/jo015628m

Reference yield: 92.0%

pyridine-2-carbaldehyde (1121-60-4) + toluene-4-sulfonamide (70-55-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 2-(hydroxy-pyridin-2-yl-methyl)-acrylic acid methyl ester (118488-74-7) + methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(2-pyridyl)propionate (364364-55-6)

Guidance literature:

With 4 Angstroem MS; 3-quinuclidinol; titanium(IV) isopropylate; In isopropyl alcohol; at 20 ℃; for 6h;

DOI:10.1021/jo0163952

Reference yield:

→ 2-(hydroxy-pyridin-2-yl-methyl)-acrylic acid methyl ester (118488-74-7)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In chloroform; at 20 ℃; for 48h;

upstream raw materials:

pyridine-2-carbaldehyde

acrylic acid methyl ester

toluene-4-sulfonamide

Downstream raw materials:

2-(Phenylcarbamoyloxy-pyridin-2-yl-methyl)-acrylic acid methyl ester

methyl indolizine-2-carboxylate

(E)-2-Phenylaminomethyl-3-pyridin-2-yl-acrylic acid methyl ester

methyl 3-formyl-5,6,7,8-tetrahydroindolizine-2-carboxylate