1,2-Ethanediol, 1-(3-methoxyphenyl)-, (1S)-

Base Information

• Chemical Name: 1,2-Ethanediol, 1-(3-methoxyphenyl)-, (1S)-
• CAS No.: 329346-52-3
• Molecular Formula: C9H12O3
• Molecular Weight: 168.192
• Mol file: 329346-52-3.mol

Synonyms:

Chemical Property of 1,2-Ethanediol, 1-(3-methoxyphenyl)-, (1S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Ethanediol, 1-(3-methoxyphenyl)-, (1S)-

There total 13 articles about 1,2-Ethanediol, 1-(3-methoxyphenyl)-, (1S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methoxystyrene (626-20-0) → (S)-1-(m-methoxy phenyl)ethane-1,2-diol (329346-52-3)

Guidance literature:

With AD-mix-α; In water; tert-butyl alcohol; at 0 ℃; for 9h;

DOI:10.1016/S0957-4166(00)00411-0

Reference yield: 77.0%

2-hydroxy-3'-methoxyacetophenone (87428-52-2) → (S)-1-(m-methoxy phenyl)ethane-1,2-diol (329346-52-3)

Guidance literature:

With dmap; (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; magnesium sulfate; benzo[1,3,2]dioxaborole; In dichloromethane; toluene; at -78 ℃; for 2.5h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201800053

Reference yield: 63.0%

3-methoxyphenylglyoxal (32025-65-3) → (S)-1-(m-methoxy phenyl)ethane-1,2-diol (329346-52-3)

Guidance literature:

With Candida parapsilosis ATCC 7330; In ethanol; water; at 25 ℃; for 5h; optical yield given as %ee; enantioselective reaction; Enzymatic reaction;

DOI:10.1016/j.tetasy.2011.12.008

upstream raw materials:

3-methoxystyrene

2-(m-methoxyphenyl)oxirane

3-methoxy-benzaldehyde

3-methoxyphenylglyoxal

Downstream raw materials:

(S)-(+)-2-(3-methoxyphenyl)oxirane

[(1S)-2-[(3S)-3-[(tert-butyldimethylsilyl)oxy]pyrrolidin-1-yl]-1-(3-methoxyphenyl)ethyl](methyl)amine

tert-butyl N-[(1S)-2-[(3S)-3-[(tert-butyldimethylsilyl)oxy]pyrrolidin-1-yl]-1-(3-methoxyphenyl)ethyl]-N-methylcarbamate

(S)-2-azido-1-(3-methoxyphenyl)ethan-1-ol