2-Methyl-3-phenylbenzofuran

Base Information

• Chemical Name: 2-Methyl-3-phenylbenzofuran
• CAS No.: 33104-08-4
• Molecular Formula: C15H12O
• Molecular Weight: 208.26
• DSSTox Substance ID: DTXSID90394884
• Nikkaji Number: J1.217.872G
• Wikidata: Q82194564
• Mol file: 33104-08-4.mol

Synonyms:2-Methyl-3-phenylbenzofuran;33104-08-4;2-methyl-3-phenyl-1-benzofuran;SCHEMBL12695627;DTXSID90394884

Chemical Property of 2-Methyl-3-phenylbenzofuran

Chemical Property:

• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 208.088815002
• Heavy Atom Count: 16
• Complexity: 232

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C2=CC=CC=C2O1)C3=CC=CC=C3

Technology Process of 2-Methyl-3-phenylbenzofuran

There total 23 articles about 2-Methyl-3-phenylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(methylsulfanyl)-3-phenylbenzofuran (1128143-83-8) + methylmagnesium chloride (676-58-4) → 2-methyl-3-phenylbenzofuran (33104-08-4)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](triphenylphosphine)nickel(II) dichloride; In tetrahydrofuran; at 25 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0034-1378914

Reference yield: 97.0%

2-(2-iodophenoxy)-1-phenylpropan-1-one → 2-methyl-3-phenylbenzofuran (33104-08-4)

Guidance literature:

2-(2-iodophenoxy)-1-phenylpropan-1-one; With methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.25h;

With toluene-4-sulfonic acid; In acetone; for 4h;

DOI:10.1055/s-2005-872690

Reference yield: 91.0%

2-phenoxy-1-phenylpropan-1-one (6640-19-3) → 2-methyl-3-phenylbenzofuran (33104-08-4)

Guidance literature:

With methanesulfonic acid; phosphorus pentoxide; at 45 ℃;

DOI:10.1177/1747519820907244

upstream raw materials:

2-benzoylphenyl acetate

2-phenoxy-1-phenylpropan-1-one

[2-(1-benzotriazol-1-ylethoxy)phenyl](phenyl)methanone

1-Phenyl-2-propyn-1-ol

Downstream raw materials:

6-acetyl-2-methyl-3-phenylbenzofuran

6-acetyl-2,3-dihydro-2-methyl-3-phenyl-2,3-epoxybenzofuran

3-methyl-3-phenylbenzofuran-2(3H)-one

2-benzoylphenyl acetate