2-PHENOXYPROPIOPHENONE

Base Information

• Chemical Name: 2-PHENOXYPROPIOPHENONE
• CAS No.: 6640-19-3
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Mol file: 6640-19-3.mol

Synonyms:2-phenoxy-1-phenyl-propan-1-one;2-Phenoxy-1-phenyl-propan-1-on;2-Phenoxypropiophenone;

Chemical Property of 2-PHENOXYPROPIOPHENONE

Chemical Property:

• Vapor Pressure: 1.38E-05mmHg at 25°C
• Boiling Point: 367.3°C at 760 mmHg
• Flash Point: 164.7°C
• PSA: 26.30000
• Density: 1.097g/cm³
• LogP: 3.33680

Purity/Quality:

2-Phenoxypropiophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENOXYPROPIOPHENONE

There total 11 articles about 2-PHENOXYPROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-bromo-1-phenyl-1-propanone (2114-00-3) + phenol (108-95-2,27073-41-2) → 2-phenoxy-1-phenylpropan-1-one (6640-19-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1055/a-1509-5655

Reference yield: 74.0%

methanol (67-56-1) + 2-phenoxy-1-phenylethanone (721-04-0) → 2-phenoxy-1-phenylpropan-1-one (6640-19-3)

Guidance literature:

With trimethylamine-N-oxide; tricarbonyl(η⁴-1,3-bis(trimethylsilyl)-4,5,6,7-tetrahydro-2H-inden-2-one)iron; potassium carbonate; at 80 ℃; for 24h;

DOI:10.1021/acscatal.8b02158

Reference yield: 54.0%

2-phenoxy-1-phenylethanone (721-04-0) + methyl iodide (74-88-4) → 2-phenoxy-1-phenylpropan-1-one (6640-19-3)

Guidance literature:

2-phenoxy-1-phenylethanone; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.333333h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.0c00199

upstream raw materials:

2-chloro-1-phenylpropan-1-one

sodium phenoxide

2-bromo-1-phenyl-1-propanone

phenol

Downstream raw materials:

1-(4-dimethylamino-phenyl)-2-phenoxy-1-phenyl-propan-1-ol

2-phenethoxybenzene

1-methyl-4-(2-phenoxyethyl)benzene

1-(4-methoxy-phenyl)-2-phenoxy-ethanone