isopropoxyacetic acid

Base Information

• Chemical Name: isopropoxyacetic acid
• CAS No.: 33445-07-7
• Molecular Formula: C5H10O3
• Molecular Weight: 118.133
• Hs Code.: 2918990090
• Mol file: 33445-07-7.mol

Synonyms:2-propan-2-yloxyethanoic acid;(1-methylethoxy)acetic acid;Acetic acid,(1-methylethoxy);2-isopropyloxyacetic acid;2-isopropoxy-acetic acid;Isopropoxy-essigsaeure;2-(1-methylethoxy)acetic acid;Isopropoxyacetic acid;Acetic acid, (1-methylethoxy)-;(propan-2-yloxy)acetic acid;

Chemical Property of isopropoxyacetic acid

Chemical Property:

• Vapor Pressure: 0.0601mmHg at 25°C
• Boiling Point: 214.5oC at 760 mmHg
• PKA: 3.49±0.10(Predicted)
• Flash Point: 89.6oC
• PSA: 46.53000
• Density: 1.05g/cm3
• LogP: 0.49600

Purity/Quality:

99%, ^*data from raw suppliers

Isopropoxyaceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of isopropoxyacetic acid

There total 9 articles about isopropoxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

isopropyl 2-isopropoxyacetate (17639-74-6) → 2-isopropoxyacetic acid (33445-07-7)

Guidance literature:

With sodium hydroxide; In methanol; water; at 25 ℃; for 1h;

DOI:10.1016/j.tet.2003.08.021

Reference yield: 89.0%

sodium monochloroacetic acid (3926-62-3) + isopropyl alcohol (67-63-0,8013-70-5) → 2-isopropoxyacetic acid (33445-07-7)

Guidance literature:

With sodium isopropylate; sodium;

Reference yield: 82.0%

sodium isopropylate (683-60-3) + chloroacetic acid (79-11-8) → 2-isopropoxyacetic acid (33445-07-7)

Guidance literature:

In isopropyl alcohol;

DOI:10.2174/1386207311316060009

upstream raw materials:

sodium isopropylate

chloroacetic acid

isopropyl alcohol

ethyl bromoacetate

Downstream raw materials:

isopropoxy-acetic acid 2-(4-methanesulfonyl-phenyl)-1,1-dimethyl-2-oxo-ethyl ester

5,5-dimethyl-4-(4-methylsulfonylphenyl)-3-(2-propoxy)-5H-furan-2-one

(S)-2-Isopropoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid

Refernces

• 1、 -. "TRIAZOLE-ISOXAZOLE COMPOUND AND MEDICAL USE THEREOF". Paragraph 3415. . Retrieved 2016/06/06.
• 2、 Zhang, Jinzhu,Dong, Kaiwu,Wang, Zheng,Ding, Kuiling. "Asymmetric hydrogenation of α- Or β-acyloxy α,β- unsaturated phosphonates catalyzed by a Rh(i) complex of monodentate phosphoramidite". supporting information; scheme or table. p. 1598 - 1601. Retrieved 2012/03/22.