Methanamine, N-[(2-methoxyphenyl)methylene]-, N-oxide

Base Information

• Chemical Name: Methanamine, N-[(2-methoxyphenyl)methylene]-, N-oxide
• CAS No.: 33499-30-8
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• DSSTox Substance ID: DTXSID30405665
• Nikkaji Number: J941.514I
• Mol file: 33499-30-8.mol

Synonyms:33499-30-8;Methanamine, N-[(2-methoxyphenyl)methylene]-, N-oxide;DTXSID30405665

Chemical Property of Methanamine, N-[(2-methoxyphenyl)methylene]-, N-oxide

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 165.078978594
• Heavy Atom Count: 12
• Complexity: 168

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+](=CC1=CC=CC=C1OC)[O-]

Technology Process of Methanamine, N-[(2-methoxyphenyl)methylene]-, N-oxide

There total 9 articles about Methanamine, N-[(2-methoxyphenyl)methylene]-, N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-methylhydroxyamine hydrochloride (4229-44-1) + ortho-anisaldehyde (135-02-4) → N-(2-methoxybenzylidene)methanamine N-oxide (33499-30-8)

Guidance literature:

With triethylamine; In chloroform; for 22h;

DOI:10.1248/cpb.50.908

Reference yield: 78.0%

N-methylhydroxyamine hydrochloride (4229-44-1) + ortho-anisaldehyde (135-02-4) → (Z)-C-(2-methoxyphenyl)-N-methyl-nitrone (33499-30-8)

Guidance literature:

With magnesium sulfate; potassium carbonate; In methanol; dichloromethane; at 20 ℃; for 20h;

DOI:10.1016/j.tetlet.2008.04.012

Reference yield: 78.0%

2-methoxy-N-methylbenzylamine (6851-80-5) → N-(2-methoxybenzylidene)methanamine N-oxide (33499-30-8)

Guidance literature:

With sodium tungstate; dihydrogen peroxide; In methanol; water; at 20 ℃;

DOI:10.1016/j.tet.2003.10.100

upstream raw materials:

N-methylhydroxyamine hydrochloride

ortho-anisaldehyde

dimethyl sulfate

2-methoxy-N-methylbenzylamine

Downstream raw materials:

2-methyl-3-(2-methoxyphenyl)-4,5-dicarbomethoxy-Δ4-isoxazoline

2-methyl-3-(2-methoxyphenyl)-4,5-dicarboethoxy-Δ4-isoxazoline

3-(2-methoxyphenyl)-2-methyl-5-trichloromethyl-Δ⁴-1,2,4-oxadiazoline

C₁₁H₁₁Cl₃N₂O₂