2-(4-CHLOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE

Base Information

• Chemical Name: 2-(4-CHLOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE
• CAS No.: 33554-30-2
• Molecular Formula: C11H12ClNO
• Molecular Weight: 209.675
• Hs Code.: 2934999090
• Mol file: 33554-30-2.mol

Synonyms:

Chemical Property of 2-(4-CHLOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE

Chemical Property:

• PSA: 21.59000
• LogP: 2.33100

Purity/Quality:

99% ，98% ^*data from raw suppliers

2-(4-CHLOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-CHLOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE

There total 15 articles about 2-(4-CHLOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chlorobenzaldehyde (104-88-1) + 2-Amino-2-methyl-1-propanol (124-68-5) → 2-(4-chlorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole (33554-30-2)

Guidance literature:

4-chlorobenzaldehyde; 2-Amino-2-methyl-1-propanol; In dichloromethane; at 25 ℃; for 20h; Inert atmosphere; Schlenk technique; Molecular sieve;

With N-Bromosuccinimide; In dichloromethane; at 25 ℃; for 4h; Inert atmosphere; Schlenk technique; Molecular sieve;

DOI:10.1021/acs.orglett.9b01350

Reference yield: 92.0%

4-Cyanochlorobenzene (623-03-0) + 2-Amino-2-methyl-1-propanol (124-68-5) → 2-(4-chlorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole (33554-30-2)

Guidance literature:

With zinc(II) chloride; In chlorobenzene; for 48h; Inert atmosphere; Reflux;

DOI:10.1039/c0cc01731k

Reference yield: 90.0%

2-[(4-chlorobenzylidene)amino]-2-methylpropan-1-ol (25457-95-8) → 2-(4-chlorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole (33554-30-2)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In methanol; at 20 ℃; for 1h;

DOI:10.1007/s10593-018-2288-9

upstream raw materials:

4-Cyanochlorobenzene

2-Amino-2-methyl-1-propanol

para-chlorobenzoic acid

p-chlorobenzoyl-1H-1,2,3-benzotriazole

Downstream raw materials:

C₁₆H₁₅ClN₂O

C₂₀H₁₇ClN₂O

5-chloro-2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)benzaldehyde

4,4'-dichlorobenzil

Refernces

• 1、 Liu, Can,Wang, Zhiming,Wang, Lei,Li, Pinhua,Zhang, Yicheng. "Palladium-catalyzed direct C2-arylation of azoles with aromatic triazenes". . p. 9209 - 9216. Retrieved 2019/11/05.
• 2、 Gutierrez, David A.,Lee, Wan-Chen Cindy,Shen, Yuning,Li, Jie Jack. "Palladium-catalyzed electrophilic C–H fluorination of arenes using oxazoline as a removable directing group". . p. 5372 - 5376. Retrieved 2016/11/11.