4-Hydroxy-6-methylnicotinic acid

Base Information

Chemical Name:4-Hydroxy-6-methylnicotinic acid
CAS No.:33821-58-8
Molecular Formula:C7H7NO3
Molecular Weight:153.14
Hs Code.:
European Community (EC) Number:675-033-2,804-816-5
DSSTox Substance ID:DTXSID50955410
Nikkaji Number:J120.393B
Wikidata:Q72494201
Mol file:33821-58-8.mol

Synonyms:4-Hydroxy-6-methylnicotinic acid;67367-33-3;33821-58-8;6-Methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid;4-hydroxy 6-methylnicotinic acid;4-Hydroxy-6-methyl-nicotinic acid;6-methyl-4-oxo-1H-pyridine-3-carboxylic Acid;MFCD04038153;4-hydroxy-6-methyl-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 4-hydroxy-6-methyl-;4-hydroxy-6-methyl-pyridine-3-carboxylic acid;6-METHYL-4(1H)-PYRIDONE-3-CARBOXYLIC ACID;6-methyl-4-hydroxynicotinic acid;4-hydroxy-6-methyl-3-picolinic acid;SCHEMBL191344;DTXSID50955410;AOJLDZLRTUWFFY-UHFFFAOYSA-N;4-hydroxy-6-methyl nicotinic acid;CHEMBRDG-BB 4002882;AMY33328;BCP17538;MFCD08059729;AKOS006280533;AKOS015842393;AB17044;AC-8749;CS-W003138;AS-13102;SY020527;FT-0600354;FT-0648875;4-Hydroxy-2-methyl-5-pyridinecarboxylic acid;6-methyl-4-(1h)-pyridone-3-carboxylic acid;EN300-85853;4-keto-6-methyl-1H-pyridine-3-carboxylic acid;6-methyl-4-hydroxy-3-pyridine carboxylic acid;O11609;A835725;J-515504;J-518897;6-methyl-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid;Z1198163899

Suppliers and Price of 4-Hydroxy-6-methylnicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Methyl-4-oxo-1,4-dihydropyridine-3-carboxylicacid
2.5g
$ 285.00

ChemBridge Corporation
6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylicacid 95%
1 g
$ 46.00

American Custom Chemicals Corporation
6-METHYL-4-OXO-1,4-DIHYDROPYRIDINE-3-CARBOXYLIC ACID 95.00%
1G
$ 818.61

Alfa Aesar
4-Hydroxy-6-methyl-nicotinic acid, 97%
5g
$ 779.00

Alfa Aesar
4-Hydroxy-6-methyl-nicotinic acid, 97%
1g
$ 197.00

Total 15 raw suppliers

Chemical Property of 4-Hydroxy-6-methylnicotinic acid

Chemical Property:

Boiling Point:311.056 °C at 760 mmHg
Flash Point:141.922 °C
PSA：70.16000
Density:1.346 g/cm³
LogP:0.38150
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:153.042593085
Heavy Atom Count:11
Complexity:275

Purity/Quality:

97% ^*data from raw suppliers

6-Methyl-4-oxo-1,4-dihydropyridine-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=O)C(=CN1)C(=O)O

Technology Process of 4-Hydroxy-6-methylnicotinic acid

There total 8 articles about 4-Hydroxy-6-methylnicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 111974-39-1
Ethyl 4-ethoxy-6-methylpyridine-3-carboxylate

: 33821-58-8
6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Guidance literature:: With hydrogenchloride; for 24h; Heating;
DOI:10.1055/s-1988-27614

Reference yield: 70.0%

: 33821-61-3
3-((dimethylamino)methylene)-6-methyl-2H-pyran-2,4(3H)-dione

: 33821-58-8
6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Guidance literature:: 3-((dimethylamino)methylene)-6-methyl-2H-pyran-2,4(3H)-dione; With ammonium hydroxide;

With dimethyl amine; In water; at 20 - 50 ℃;

With hydrogenchloride; at 20 ℃; Further stages.;
DOI:10.1016/j.bmcl.2008.02.036

Reference yield:

: 86129-63-7
ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate

: 33821-58-8
6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Na / 3 h / 60 °C

2: 81 percent / KOAc, H₂ / 10percent Pd/C / propan-2-ol / 48 h / 20 °C / 3000.2 Torr

3: conc. aq. HCl / 24 h / Heating

With hydrogenchloride; hydrogen; potassium acetate; sodium; palladium on activated charcoal; In isopropyl alcohol;
DOI:10.1055/s-1988-27614