3-Pyridinecarboxylicacid,4-ethoxy-6-methyl-,ethylester(9CI)

Base Information

• Chemical Name: 3-Pyridinecarboxylicacid,4-ethoxy-6-methyl-,ethylester(9CI)
• CAS No.: 111974-39-1
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.245
• Hs Code.: 2933399090
• Mol file: 111974-39-1.mol

Synonyms:3-Pyridinecarboxylicacid,4-ethoxy-6-methyl-,ethylester(9CI)

Chemical Property of 3-Pyridinecarboxylicacid,4-ethoxy-6-methyl-,ethylester(9CI)

Chemical Property:

• Boiling Point: 299℃
• PKA: 5.31±0.18(Predicted)
• Flash Point: 134℃
• PSA: 48.42000
• Density: 1.079
• LogP: 1.96540

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylicacid,4-ethoxy-6-methyl-,ethylester(9CI)

There total 3 articles about 3-Pyridinecarboxylicacid,4-ethoxy-6-methyl-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Ethyl 2-chloro-4-ethoxy-6-methylpyridine-3-carboxylate (111953-15-2) → Ethyl 4-ethoxy-6-methylpyridine-3-carboxylate (111974-39-1)

Guidance literature:

With hydrogen; potassium acetate; palladium on activated charcoal; In isopropyl alcohol; at 20 ℃; for 48h; under 3000.2 Torr;

DOI:10.1055/s-1988-27614

Reference yield:

ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate (86129-63-7) → Ethyl 4-ethoxy-6-methylpyridine-3-carboxylate (111974-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / Na / 3 h / 60 °C

2: 74 percent / KOAc, H₂ / 10percent Pd/C / propan-2-ol / 48 h / 20 °C / 3000.2 Torr

With hydrogen; potassium acetate; sodium; palladium on activated charcoal; In isopropyl alcohol;

DOI:10.1055/s-1988-27614

Reference yield:

ethyl 1,2-dihydro-2-oxo-4-hydroxy-6-methylpyridine-3-carboxylate (10350-10-4) → Ethyl 4-ethoxy-6-methylpyridine-3-carboxylate (111974-39-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / POCl₃ / 4 h / 140 °C

2: 76 percent / Na / 3 h / 60 °C

3: 74 percent / KOAc, H₂ / 10percent Pd/C / propan-2-ol / 48 h / 20 °C / 3000.2 Torr

With hydrogen; potassium acetate; sodium; trichlorophosphate; palladium on activated charcoal; In isopropyl alcohol;

DOI:10.1055/s-1988-27614

upstream raw materials:

Ethyl 2-chloro-4-ethoxy-6-methylpyridine-3-carboxylate

ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate

ethyl 1,2-dihydro-2-oxo-4-hydroxy-6-methylpyridine-3-carboxylate

Downstream raw materials:

6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid