N-(tert-Butoxycarbonyl)glycyl-L-phenylalaninamide

Base Information

Chemical Name:N-(tert-Butoxycarbonyl)glycyl-L-phenylalaninamide
CAS No.:33900-05-9
Molecular Formula:C16H23N3O4
Molecular Weight:321.376
Hs Code.:
DSSTox Substance ID:DTXSID00556037
Wikidata:Q82437505

Synonyms:33900-05-9;N-(tert-Butoxycarbonyl)glycyl-L-phenylalaninamide;DTXSID00556037;N-t-butyloxycarbonylglycyl-l-phenylalanine amide

Suppliers and Price of N-(tert-Butoxycarbonyl)glycyl-L-phenylalaninamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-(tert-Butoxycarbonyl)glycyl-L-phenylalaninamide

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:321.16885622
Heavy Atom Count:23
Complexity:426

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCC(=O)NC(CC1=CC=CC=C1)C(=O)N
Isomeric SMILES:CC(C)(C)OC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N

Technology Process of N-(tert-Butoxycarbonyl)glycyl-L-phenylalaninamide

There total 8 articles about N-(tert-Butoxycarbonyl)glycyl-L-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 81092-89-9
L-phenylalanine amide trifluoroacetate

: 91837-43-3
1,3-dioxoisoindolin-2-yl (tert-butoxycarbonyl)glycinate

: 33900-05-9
tert-butyl (S)-N-{2-[(2-amino-1-benzyl-2-oxoethyl)amino]-2-oxoethyl}carbamate

Guidance literature:: With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 22 ℃; for 18h;
DOI:10.1007/BF00951309

Reference yield: 70.0%

: 4530-20-5
BOC-glycine

: 65864-22-4
(S)-2-amino-3-phenylpropionamide hydrochloride

: 33900-05-9
tert-butyl (S)-N-{2-[(2-amino-1-benzyl-2-oxoethyl)amino]-2-oxoethyl}carbamate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1021/jm9509511

Reference yield:

: 4530-20-5
BOC-glycine

: 33900-05-9
tert-butyl (S)-N-{2-[(2-amino-1-benzyl-2-oxoethyl)amino]-2-oxoethyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine / tetrahydrofuran / 0.33 h / -15 °C

2: tetrahydrofuran / 2.5 h / -15 - 20 °C

With 4-methyl-morpholine; In tetrahydrofuran;
DOI:10.1021/jm00151a018