L-Aspartic acid, N-[(phenylMethoxy)carbonyl]-L-alanyl-, 24-(1,1-diMethylethyl) ester (9CI)

Base Information

Chemical Name:L-Aspartic acid, N-[(phenylMethoxy)carbonyl]-L-alanyl-, 24-(1,1-diMethylethyl) ester (9CI)
CAS No.:3408-50-2
Molecular Formula:C19H26N2O7
Molecular Weight:394.425
Hs Code.:
Mol file:3408-50-2.mol

Synonyms:(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-succinic acid 4-tert-butyl ester;L-Aspartic acid, N-[(phenylmethoxy)carbonyl]-L-alanyl-, 24-(1,1-dimethylethyl) ester;Z-Ala-Asp(OtBu)-OH;[(N-benzyloxycarbonyl)-L-alaninyl]-L-aspartic acid [beta]-tert-butyl ester;

Suppliers and Price of L-Aspartic acid, N-[(phenylMethoxy)carbonyl]-L-alanyl-, 24-(1,1-diMethylethyl) ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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ChemScene
L-Asparticacid,N-[(phenylmethoxy)carbonyl]-L-alanyl-,24-(1,1-dimethylethyl)ester9CI
1g
$ 385.00

Total 4 raw suppliers

Chemical Property of L-Aspartic acid, N-[(phenylMethoxy)carbonyl]-L-alanyl-, 24-(1,1-diMethylethyl) ester (9CI)

Chemical Property:

PSA：131.03000
LogP:2.38430

Purity/Quality:

99% ^*data from raw suppliers

L-Asparticacid,N-[(phenylmethoxy)carbonyl]-L-alanyl-,24-(1,1-dimethylethyl)ester9CI ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Aspartic acid, N-[(phenylMethoxy)carbonyl]-L-alanyl-, 24-(1,1-diMethylethyl) ester (9CI)

There total 4 articles about L-Aspartic acid, N-[(phenylMethoxy)carbonyl]-L-alanyl-, 24-(1,1-diMethylethyl) ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 3057-74-7
L-Asp(t-Bu)

: 3401-36-3
(N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester

: 3408-50-2
[(N-benzyloxycarbonyl)-L-alaninyl]-L-aspartic acid [beta]-tert-butyl ester

Guidance literature:: L-Asp(t-Bu); With bis(trimethylsilyl)trifluoroacetamide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

(N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm050307e

Reference yield:

: 3190-64-5
(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-succinic acid 4-tert-butyl ester 1-methyl ester

: 3408-50-2
[(N-benzyloxycarbonyl)-L-alaninyl]-L-aspartic acid [beta]-tert-butyl ester

Guidance literature:: With sodium hydroxide; In ethanol;

Reference yield:

: 1142-20-7
N-Cbz-Ala

: 3408-50-2
[(N-benzyloxycarbonyl)-L-alaninyl]-L-aspartic acid [beta]-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N, DCC / CH₂Cl₂

2: aq. NaOH / ethanol

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;