4-CHLORO-6-PHENYLPYRIMIDINE

Base Information

• Chemical Name: 4-CHLORO-6-PHENYLPYRIMIDINE
• CAS No.: 3435-26-5
• Molecular Formula: C10H7ClN2
• Molecular Weight: 190.632
• Hs Code.: 2933599090
• Mol file: 3435-26-5.mol

Synonyms:4-chloro-6-phenyl-pyrimidine;4-Chlor-6-phenyl-pyrimidin;6-Chlor-4-phenyl-pyrimidin;Pyrimidine,4-chloro-6-phenyl;6-chloro-4-phenylpyrimidine;

Chemical Property of 4-CHLORO-6-PHENYLPYRIMIDINE

Chemical Property:

• PSA: 25.78000
• LogP: 2.79700
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-6-phenylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-6-PHENYLPYRIMIDINE

There total 6 articles about 4-CHLORO-6-PHENYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

4-hydroxy-6-phenylpyrimidine (4891-69-4) → 4-chloro-6-phenylpyrimidine (3435-26-5)

Guidance literature:

With trichlorophosphate;

Reference yield: 83.0%

→ 4-chloro-6-phenylpyrimidine (3435-26-5)

Guidance literature:

Reference yield: 64.0%

4,6-dichloropyrimidine (1193-21-1) + phenylboronic acid (98-80-6) → 4-chloro-6-phenylpyrimidine (3435-26-5)

Guidance literature:

With palladium diacetate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; water; at 60 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2016.11.052

upstream raw materials:

4-phenyl-6(1H)-pyrimidinone

4,6-dichloropyrimidine

phenylboronic acid

6-phenyl-2-thiouracil

Downstream raw materials:

4-phenylpyrimidine

4-ethyl-6-phenylpyrimidine

dimethyl 4-phenyl-6-pyrimidylmalonate

4-azido-6-phenylpyrimidine