6-phenyl-4-pyrimidinol

Base Information

• Chemical Name: 6-phenyl-4-pyrimidinol
• CAS No.: 4891-69-4
• Molecular Formula: C10H8N2O
• Molecular Weight: 172.186
• Hs Code.: 2933599090
• Mol file: 4891-69-4.mol

Synonyms:6-PHENYL-4-PYRIMIDINOL;6-PHENYL-PYRIMIDIN-4-OL;4-hydroxy-6-phenylpyriMidine(Ⅱ);6-PhenylpyriMidin-4(1H)-one

Chemical Property of 6-phenyl-4-pyrimidinol

Chemical Property:

• Vapor Pressure: 0.000236mmHg at 25°C
• Melting Point: 273.3 - 274.5 °C
• Boiling Point: 325°C at 760 mmHg
• Flash Point: 150.4°C
• PSA: 46.01000
• Density: 1.2g/cm³
• LogP: 1.84920

Purity/Quality:

99% ^*data from raw suppliers

6-phenylpyrimidin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-phenyl-4-pyrimidinol

There total 18 articles about 6-phenyl-4-pyrimidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-chloro-6-phenylpyrimidine (3435-26-5) → 4-Hydroxyamino-6-phenylpyrimidine (111396-70-4) + 4-phenyl-6(1H)-pyrimidinone (4891-69-4)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In ethanol; for 1h; Product distribution; Heating; other base (Na₂CO₃);

DOI:10.1007/BF00471808

Reference yield: 71.0%

ethyl 3-amino-3-phenylprop-2-enoate (33831-72-0) + orthoformic acid triethyl ester (122-51-0) → 6-phenylpyrimidin-4(1H)-one (156647-97-1,156647-98-2,4891-69-4) + ethyl 4-phenylpyrimidine-5-carboxylate (100724-16-1)

Guidance literature:

With ammonium acetate; zinc(II) chloride; In toluene; at 100 ℃; for 48h; Inert atmosphere;

DOI:10.1021/ol900382j

Reference yield: 40.0%

4-hydroxy-2-mercapto-6-phenylpyrimidine (36822-11-4) → 4-hydroxy-6-phenylpyrimidine (4891-69-4)

Guidance literature:

With ammonia; nickel; In water; at 20 ℃; for 3h; Heating / reflux;

upstream raw materials:

4-Amino-6-phenylpyrimidine

6-phenyl-2-thiouracil

5-formylamino-3-phenylisoxazole

ethyl 3-oxo-3-phenylpropionate

Downstream raw materials:

4-chloro-6-phenylpyrimidine

4,5-dichloro-6-phenylpyrimidine

4-phenylpyrimidine

2-<(6-phenyl-4-pyrimidinyl)oxy>propionic acid ethyl ester

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