3,5-Dimethoxy-4-(2-methoxyethoxy)benzaldehyde

Base Information

• Chemical Name: 3,5-Dimethoxy-4-(2-methoxyethoxy)benzaldehyde
• CAS No.: 65321-43-9
• Molecular Formula: C12H16 O5
• Molecular Weight: 240.256
• Hs Code.: 2912499000
• European Community (EC) Number: 265-696-2
• DSSTox Substance ID: DTXSID20983947
• Nikkaji Number: J307.377G
• Wikidata: Q82970959
• Mol file: 65321-43-9.mol

Synonyms:3,5-Dimethoxy-4-(2-methoxyethoxy)benzaldehyde;65321-43-9;EINECS 265-696-2;SCHEMBL7467304;DTXSID20983947;HZEDXSOUEKTFMT-UHFFFAOYSA-N;3,5-dimethoxy-4-methoxyethoxy-benzaldehyde;FT-0739616

Chemical Property of 3,5-Dimethoxy-4-(2-methoxyethoxy)benzaldehyde

Chemical Property:

• Vapor Pressure: 1.34E-05mmHg at 25°C
• Boiling Point: 367.7°C at 760 mmHg
• Flash Point: 162.9°C
• PSA: 53.99000
• Density: 1.13g/cm³
• LogP: 1.54150
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 240.09977361
• Heavy Atom Count: 17
• Complexity: 207

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOC1=C(C=C(C=C1OC)C=O)OC

Technology Process of 3,5-Dimethoxy-4-(2-methoxyethoxy)benzaldehyde

There total 3 articles about 3,5-Dimethoxy-4-(2-methoxyethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-methoxy-ethyl p-toluenesulfonyloxy ester (17178-10-8,58320-73-3) + syringic aldehyde (134-96-3) → 3,5-Dimethoxy-4-(2-methoxyethoxy)-benzaldehyd (65321-43-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 160 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;

DOI:10.1021/jm400665c

Reference yield: 72.0%

bis(3-bromopropyl) ether (58929-72-9) + syringic aldehyde (134-96-3) → 3,5-Dimethoxy-4-(2-methoxyethoxy)-benzaldehyd (65321-43-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

2-chloroethyl methyl ether (627-42-9) + syringic aldehyde (134-96-3) → 3,5-Dimethoxy-4-(2-methoxyethoxy)-benzaldehyd (65321-43-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 6h; Heating;

upstream raw materials:

2-chloroethyl methyl ether

syringic aldehyde

bis(3-bromopropyl) ether

2-methoxy-ethyl p-toluenesulfonyloxy ester

Downstream raw materials:

4-(4-(2-methoxyethoxy)-3,5-dimethoxybenzyl)-7-ethoxyisoquinolin-8-ol

α-<3,5-Dimethoxy-4-(2-methoxyethoxy)>-benzyl-β-(2-methoxyethoxy)-acrylnitril