2-(4-NITROBENZOYL)THIOPHENE

Base Information

• Chemical Name: 2-(4-NITROBENZOYL)THIOPHENE
• CAS No.: 34715-92-9
• Molecular Formula: C11H7NO3S
• Molecular Weight: 233.247
• Hs Code.: 2934999090
• Mol file: 34715-92-9.mol

Synonyms:2-(3,4-DICHLOROPHENYL)-4-QUINOLINECARBOXYLIC ACID;2-thienyl p-nitrophenyl ketone;p-NO2C6H4C(O)-2-C4H3S;(4-nitrophenyl)(thiophen-2-yl)methanone;4-nitrophenyl 2-thienyl ketone;2-(p-nitrobenzoyl)thiophene;

Chemical Property of 2-(4-NITROBENZOYL)THIOPHENE

Chemical Property:

• Vapor Pressure: 7.46E-07mmHg at 25°C
• Boiling Point: 407.6oC at 760 mmHg
• Flash Point: 200.3oC
• PSA: 91.13000
• Density: 1.381g/cm3
• LogP: 3.41050

Purity/Quality:

97% ^*data from raw suppliers

2-(4-nitrobenzoyl)thiophene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-NITROBENZOYL)THIOPHENE

There total 21 articles about 2-(4-NITROBENZOYL)THIOPHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-[2]thienyl-mercury (5980-89-2) + 4-nitro-benzoyl chloride (122-04-3) → (4-nitro-phenyl)-thiophen-2-yl-methanone (34715-92-9) + 2,2'-Bithiophene (492-97-7)

Guidance literature:

With sodium iodide; dichloro bis(acetonitrile) palladium(II); In acetone; acyldemetallation by stirring a mixt. of acyl chloride, R2Hg, NaI and Pd catalyst in acetone, room temp., 10 min; monitoring by UV; dilution (H2O); extraction (ether); washing (aq. NaI); drying over MgSO4; evapn.;

DOI:10.1016/0022-328X(89)87037-8

Reference yield: 98.0%

di-[2]thienyl-mercury (5980-89-2) + 4-nitro-benzoyl chloride (122-04-3) → (4-nitro-phenyl)-thiophen-2-yl-methanone (34715-92-9)

Guidance literature:

With sodium iodide; dichloro bis(acetonitrile) palladium(II); In acetone; 20°C, 10 min; thin-layer chromy., UV spectroscopy;

DOI:10.1007/BF00954101

Reference yield: 93.0%

thiophene (188290-36-0,8014-23-1,25233-34-5) + 4-nitro-benzoic acid (62-23-7) → (4-nitro-phenyl)-thiophen-2-yl-methanone (34715-92-9)

Guidance literature:

With silica gel supported aluminium trichloride; at 60 ℃; for 2.5h; regioselective reaction;

DOI:10.3906/kim-0912-359

upstream raw materials:

thiophene

4-nitro-benzoyl chloride

5-nitro-2-(thiophene-2-carbonyl)-benzoic acid

di-[2]thienyl-mercury

Downstream raw materials:

1-(4-nitrophenyl)-1-(2-thienyl)-4-methyl-4-(tetrahydropyran-2-yloxy)-pent-2-yn-1-ol

2-(3-cyano-4-hydroxybenzoyl)thiophene

2-(4-Aminobenzoyl)thiophene

Refernces

• 1、 Jadhav, Sanjay,Jagdale, Ashutosh,Kamble, Santosh,Kumbhar, Arjun,Salunkhe, Rajshri. "Palladium nanoparticles supported on a titanium dioxide cellulose composite (PdNPs@TiO2-Cell) for ligand-free carbon-carbon cross coupling reactions". . p. 3406 - 3420. Retrieved 2016/01/25.
• 2、 Bindu,Naini, Shravan Reddy,Shanmukha Rao,Dubey,Pal, Sarbani. "TFAA/H3PO4-Mediated C-2 acylation of thiophene: A direct synthesis of known and novel thiophene derivatives of pharmacological interest". . p. 586 - 593. Retrieved 2014/06/10.