N-(4-chlorobenzyl)-4-methoxybenzamide

Base Information

• Chemical Name: N-(4-chlorobenzyl)-4-methoxybenzamide
• CAS No.: 351988-72-2
• Molecular Formula: C15H14ClNO2
• Molecular Weight: 275.73000
• Mol file: 351988-72-2.mol

Synonyms:

Chemical Property of N-(4-chlorobenzyl)-4-methoxybenzamide

Chemical Property:

• Boiling Point: 466.7±35.0 °C(Predicted)
• PKA: 14.14±0.46(Predicted)
• PSA: 38.33000
• Density: 1.217±0.06 g/cm3(Predicted)
• LogP: 3.66950

Purity/Quality:

99% ^*data from raw suppliers

N-(4-CHLOROBENZYL)-4-METHOXYBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-chlorobenzyl)-4-methoxybenzamide

There total 5 articles about N-(4-chlorobenzyl)-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-methoxyphenylacetamide (3424-93-9) + para-Chlorobenzyl alcohol (873-76-7) → N-(4-Chlorobenzyl)-4-methoxybenzamide (351988-72-2)

Guidance literature:

With C₂₃H₂₄ClIrN₃OS⁽¹⁺⁾*F₆P^(1-); caesium carbonate; In toluene; at 120 ℃;

DOI:10.1016/j.cclet.2019.08.049

Reference yield: 69.0%

4-Methoxybenzenethiol (696-63-9) + carbon monoxide (201230-82-2) + 4-chlorobenzylamine (104-86-9) → N-(4-Chlorobenzyl)-4-methoxybenzamide (351988-72-2) + 4,4'-dimethoxyphenyl disulfide (5335-87-5)

Guidance literature:

With dicobalt octacarbonyl; acetic acid; In toluene; at 220 ℃; for 1h; under 11251.1 Torr; Reagent/catalyst; Pressure; Catalytic behavior; Inert atmosphere;

DOI:10.1039/d1ra04736a

Reference yield:

4-chlorobenzylamine (104-86-9) + 4-Dimethylamino-1-(4-methoxy-benzoyl)-pyridinium; chloride → N-(4-Chlorobenzyl)-4-methoxybenzamide (351988-72-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 ℃;

DOI:10.1021/acscatal.8b00757

upstream raw materials:

4-methoxybenzonitrile

para-Chlorobenzyl alcohol

4-chloromethoxybenzene

4-chlorobenzylamine

Refernces

• 1、 Yao, Wei,Zhang, Yilin,Zhu, Haiyan,Ge, Chenyang,Wang, Dawei. "The synthesis and structure of pyridine-oxadiazole iridium complexes and catalytic applications: Non-coordinating-anion-tuned selective C–N bond formation". . p. 701 - 705. Retrieved 2019/09/30.
• 2、 Polshettiwar, Vivek,Varma, Rajender S.. "Nafion-catalyzed microwave-assisted Ritter reaction: an atom-economic solvent-free synthesis of amides". . p. 2661 - 2664. Retrieved 2008/09/19.