6-Methoxy-1-benzofuran-2-carboxamide

Base Information

Chemical Name:6-Methoxy-1-benzofuran-2-carboxamide
CAS No.:35351-23-6
Molecular Formula:C10H9NO3
Molecular Weight:191.18300
Hs Code.:
DSSTox Substance ID:DTXSID60528139
Wikidata:Q82397530
Mol file:35351-23-6.mol

Synonyms:6-Methoxy-1-benzofuran-2-carboxamide;35351-23-6;DTXSID60528139

Suppliers and Price of 6-Methoxy-1-benzofuran-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 6-Methoxy-1-benzofuran-2-carboxamide

Chemical Property:

PSA：65.46000
LogP:2.24060
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:191.058243149
Heavy Atom Count:14
Complexity:231

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C=C(O2)C(=O)N

Technology Process of 6-Methoxy-1-benzofuran-2-carboxamide

There total 1 articles about 6-Methoxy-1-benzofuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.5%

: 50635-23-9
(3-methoxyphenoxy)acetonitrile

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 35351-23-6
methoxy-6 carboxamido-2 benzofuranne

: 50551-61-6
6-methoxybenzofuran-2-carboxylic acid

: 88710-29-6
4-formyl-3-methoxyphenoxyacetonitrile

: 108656-11-7
2-(2-formyl-5-methoxyphenoxy)acetonitrile

Guidance literature:: With trichlorophosphate; at 100 ℃; for 15h; Further byproducts given. Yields of byproduct given;

Reference yield:

: 35351-23-6
methoxy-6 carboxamido-2 benzofuranne

: 150985-52-7
1-ethyl-2-(6-methoxybenzofuran-2-yl)-1H-imidazole hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / 75 °C

2.1: hydrogenchloride / diethyl ether / 48 h / 4 °C

3.1: methanol / 16 h / 60 °C

4.1: hydrogenchloride / water / 16 h / 60 °C

5.1: sodium hydroxide

5.2: 0.5 h / 20 °C

5.3: 0.75 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; trichlorophosphate; In methanol; diethyl ether; water; 1,2-dichloro-ethane;
DOI:10.1016/j.ejmech.2021.113540