1-Chloro-N,N-dimethylmethanesulfonamide

Base Information

• Chemical Name: 1-Chloro-N,N-dimethylmethanesulfonamide
• CAS No.: 35427-68-0
• Molecular Formula: C3H8ClNO2S
• Molecular Weight: 157.61900
• Hs Code.: 2935009090
• European Community (EC) Number: 859-759-9
• DSSTox Substance ID: DTXSID70448718
• Nikkaji Number: J1.903.205A
• Wikidata: Q82267838
• Mol file: 35427-68-0.mol

Synonyms:1-CHLORO-N,N-DIMETHYLMETHANESULFONAMIDE;35427-68-0;Methanesulfonamide, 1-chloro-N,N-dimethyl-;n,n-dimethylchloromethanesulfonamide;SCHEMBL7099319;DTXSID70448718;chloro-N,N-dimethylmethanesulfonamide;MFCD03085928;AKOS009158692;LS-07043;EN300-304775

Chemical Property of 1-Chloro-N,N-dimethylmethanesulfonamide

Chemical Property:

• PSA: 45.76000
• LogP: 1.15490
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 156.9964274
• Heavy Atom Count: 8
• Complexity: 145

Purity/Quality:

99% ^*data from raw suppliers

1-chloro-N,N-dimethylmethanesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)S(=O)(=O)CCl

Technology Process of 1-Chloro-N,N-dimethylmethanesulfonamide

There total 2 articles about 1-Chloro-N,N-dimethylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

monochloromethanesulfonyl chloride (3518-65-8) + dimethyl amine (124-40-3) → N,N-dimethyl-(chloromethane)sulphonamide (35427-68-0)

Guidance literature:

In diethyl ether;

Reference yield:

→ N,N-dimethyl-(chloromethane)sulphonamide (35427-68-0)

Guidance literature:

Reference yield: 92.0%

N,N-dimethyl-(chloromethane)sulphonamide (35427-68-0) + [5-(4-nitrophenyl)-10,15,20-triphenylporphyrinato]zinc(II) → N,N-dimethyl-C-{[2-nitro-5-(10,15,20-triphenylporphyrinato-5-yl)phenyl]methanesulphonamide}

Guidance literature:

N,N-dimethyl-(chloromethane)sulphonamide; [5-(4-nitrophenyl)-10,15,20-triphenylporphyrinato]zinc(II); With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

With sulfuric acid; trifluoroacetic acid; at 20 ℃; for 3h;

DOI:10.3987/COM-02-9514

upstream raw materials:

monochloromethanesulfonyl chloride

dimethyl amine

Downstream raw materials:

(2R,3R)-3-Phenyl-oxirane-2-sulfonic acid dimethylamide

1,2-bis(N,N-dimethylsulfamoyl)-1,1a,1b,2-tetrahydro-1a-phenylbisazirino<1,2-a:2',1'-c>quinoxaline

N,N-dimethyl-C-(5-phenyl-1,2,4-triazine)-methanesulphonamide

(3-([(dimethylamino)sulfonyl]methyl)-2-nitro-5,10,15,20-tetraphenylporphyrinato)zinc(II)

Refernces

• 1、 Brienne,Varech,Leclercq,Jacques,Radembino,Dessalles,Mahuzier,Gueyouche,Bories,Loiseau,Gayral. "New antifilarial agents. 1. Epoxy sulfonamides and ethynesulfonamides". . p. 2232 - 2239. Retrieved 2007/10/02.