2-Butanone, 3-methyl-3-(phenylthio)-

Base Information

• Chemical Name: 2-Butanone, 3-methyl-3-(phenylthio)-
• CAS No.: 35875-02-6
• Molecular Formula: C11H14OS
• Molecular Weight: 194.298
• Mol file: 35875-02-6.mol

Synonyms:

Chemical Property of 2-Butanone, 3-methyl-3-(phenylthio)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Butanone, 3-methyl-3-(phenylthio)-

There total 8 articles about 2-Butanone, 3-methyl-3-(phenylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2RS)-3-methyl-3-phenylsulfanylbutan-2-ol (58468-92-1) → 2-methyl-2-phenylsulfanylbutan-3-one (35875-02-6)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃;

DOI:10.1039/b208558e

Reference yield:

3-methyl-butan-2-one (563-80-4) + diphenyldisulfane (882-33-7) → 2-methyl-2-phenylsulfanylbutan-3-one (35875-02-6) + 3-methyl-1-phenylsulfanyl-butan-2-one (71221-49-3)

Guidance literature:

With diphenyl diselenide; caesium carbonate; In 2,4-dichlorophenoxyacetic acid dimethylamine; at 100 ℃; for 7h; air atmosphere;

DOI:10.1246/bcsj.20110127

Reference yield:

2-methyl-2-(phenylthio)propanal (63996-66-7) → 2-methyl-2-phenylsulfanylbutan-3-one (35875-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / diethyl ether / 1 h / 20 °C

2: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 20 °C

With pyridinium chlorochromate; In diethyl ether; dichloromethane;

DOI:10.1039/b208558e

upstream raw materials:

3-bromo-3-methyl-2-butanone

sodium thiophenolate

1-(phenylsulfanyl)acetone

methyl iodide

Downstream raw materials:

N-(4-hydroxy-5-methyl-5-phenylsulfanyl-hexyl)-formamide

4-hydroxy-5-methyl-5-phenylsulfanyl-hexanoic acid amide

(4-hydroxy-5-methyl-5-phenylsulfanyl-hexyl)-carbamic acid methyl ester

(4-hydroxy-5-methyl-5-phenylsulfanyl-hexyl)-carbamic acid phenyl ester

Refernces

• 1、 House, David,Kerr, Fraser,Warren, Stuart. "Scope and limitation of the [1,2]-phenylsulfanyl (PhS) migration in the synthesis of tetrahydrofurans and tetrahydropyrans from common triol precursors". . p. 2652 - 2662. Retrieved 2007/10/03.