(S)-ISOPARATHIONMETHYL

Base Information

• Chemical Name: (S)-ISOPARATHIONMETHYL
• CAS No.: 135513-16-5
• Molecular Formula: C8H10NO5PS
• Molecular Weight: 263.2075
• Mol file: 135513-16-5.mol

Synonyms:(S)-Thiophosphoric acid O,S-dimethyl ester O'-(4-nitro-phenyl) ester;(S)-isoparathion methyl;(S)-O,S-dimethyl O-(p-nitrophenyl)phosphorothiolate;

Chemical Property of (S)-ISOPARATHIONMETHYL

Chemical Property:

• Vapor Pressure: 2.25E-05mmHg at 25°C
• Boiling Point: 371.1°C at 760 mmHg
• Flash Point: 178.3°C
• PSA: 116.46000
• Density: 1.413g/cm³
• LogP: 3.61430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-ISOPARATHIONMETHYL

There total 8 articles about (S)-ISOPARATHIONMETHYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methanol (67-56-1) + p-Nitrophenoxy S-methyl <(2S)-2-(carbethoxy)-pyrrolidinyl>phosphorothioate (135505-96-3,135505-97-4) → (S)-O,S-dimethyl O-(p-nitrophenyl)phosphorothiolate (135513-16-5)

Guidance literature:

With boron trifluoride methanol complex;

DOI:10.1021/jo00016a042

Reference yield: 51.3%

C8H10NO4PS2 (1195996-15-6) → (S)-O,S-dimethyl O-(p-nitrophenyl)phosphorothiolate (135513-16-5)

Guidance literature:

With dihydrogen peroxide; chloroperoxidase; In ethyl acetate; at 20 ℃; for 730.5h; pH=5; stereoselective reaction; aq. citrate buffer;

DOI:10.1016/j.tetasy.2009.07.031

Reference yield:

methyl iodide (74-88-4) → thiophosphoric acid O,S-dimethyl ester-O'-(4-nitro-phenyl ester) (597-89-7,135513-15-4,135513-16-5,135559-63-6)

Guidance literature:

With acetonitrile; (-)-thiophosphoric acid O,S-dimethyl ester-O'-<4-nitro-phenyl ester>;

upstream raw materials:

parathion-methyl

methyl iodide

methanol

p-Nitrophenoxy S-methyl <(2S)-2-(carbethoxy)-pyrrolidinyl>phosphorothioate

Downstream raw materials:

C₈H₁₀NO₄PS₂

Refernces

• 1、 Ryu, Seungmin,Jackson, John A.,Thompson, Charles M.. "Methanolysis of Phosphoramidates with Boron Trifluoride-Methanol Complex". . p. 4999 - 5002. Retrieved 2007/10/02.