Methanesulfonamide, N-(4-fluorophenyl)-

Base Information

• Chemical Name: Methanesulfonamide, N-(4-fluorophenyl)-
• CAS No.: 35980-24-6
• Molecular Formula: C7H8FNO2S
• Molecular Weight: 189.21
• Mol file: 35980-24-6.mol

Synonyms:N-(p-fluorophenyl)methanesulfonamide;N-(4-fluorophenyl)methanesulfonamide;4-fluoro-N-methanesulfonyl benzenamine;N-(4-fluorophenyl)methanesulfonate;

Chemical Property of Methanesulfonamide, N-(4-fluorophenyl)-

Chemical Property:

• PSA: 54.55000
• LogP: 2.35100

Purity/Quality:

95% ^*data from raw suppliers

N-(4-Fluorophenyl)methanesulfonamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanesulfonamide, N-(4-fluorophenyl)-

There total 12 articles about Methanesulfonamide, N-(4-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-fluoroaniline (371-40-4) + Methanesulfonic anhydride (7143-01-3) → 4-fluoro-N-methanesulfonyl benzenamine (35980-24-6)

Guidance literature:

4-fluoroaniline; Methanesulfonic anhydride; With triethylamine; In dichloromethane; at 20 ℃;

With sodium hydroxide; In methanol; water; at 20 ℃;

DOI:10.1016/j.tetlet.2008.08.054

Reference yield: 89.0%

methanesulfonyl chloride (124-63-0) + 4-fluoroaniline (371-40-4) → 4-fluoro-N-methanesulfonyl benzenamine (35980-24-6)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c4cc04738a

Reference yield: 82.0%

methanesulfonamide (3144-09-0) + 4-fluoro-1-iodobenzene (352-34-1) → 4-fluoro-N-methanesulfonyl benzenamine (35980-24-6)

Guidance literature:

With copper(I) oxide; caesium carbonate; In water; at 130 ℃; for 24h; Sealed tube;

DOI:10.1002/ejoc.201301561 DOI:10.1002/ejoc.201301561

upstream raw materials:

N-phenylmethanesulfonamide

methanesulfonyl chloride

4-fluoroaniline

N_.N-Bis(methylsulfonyl)-4-fluor-anilin

Downstream raw materials:

4-(methylsulfonylamino)phenol

C₂₆H₂₈N₂O₅S