Benzamide, 4-(dimethylamino)-N,N-dimethyl-

Base Information

• Chemical Name: Benzamide, 4-(dimethylamino)-N,N-dimethyl-
• CAS No.: 21566-11-0
• Molecular Formula: C11H16N2O
• Molecular Weight: 192.261
• DSSTox Substance ID: DTXSID70175911
• Nikkaji Number: J874.063A
• Wikidata: Q83046249
• Mol file: 21566-11-0.mol

Synonyms:Benzamide, 4-(dimethylamino)-N,N-dimethyl-;4-(dimethylamino)-N,N-dimethylbenzamide;21566-11-0;SCHEMBL24783913;DTXSID70175911;AKOS008933147;4-Dimethylamino-N,N-dimethyl-benzamide;N,N-dimethyl-p-(dimethylamino)benzamide;Z32014568

Chemical Property of Benzamide, 4-(dimethylamino)-N,N-dimethyl-

Chemical Property:

• Vapor Pressure: 8.53E-05mmHg at 25°C
• Boiling Point: 340.6°C at 760 mmHg
• Flash Point: 149.5°C
• Density: 1.052g/cm³
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 192.126263138
• Heavy Atom Count: 14
• Complexity: 194

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC=C(C=C1)C(=O)N(C)C

Technology Process of Benzamide, 4-(dimethylamino)-N,N-dimethyl-

There total 8 articles about Benzamide, 4-(dimethylamino)-N,N-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

p-N,N-dimethylaminobenzoic acid (619-84-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N,N-dimethyl-p-(dimethylamino)benzamide (21566-11-0)

Guidance literature:

With dipotassium peroxodisulfate; (p-cymene)ruthenium(II) chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; at 160 ℃; for 12h;

DOI:10.1016/j.tet.2016.10.043

Reference yield: 85.0%

4-(dimethylamino)benzoyl chloride (4755-50-4) + dimethyl amine (124-40-3) → N,N-dimethyl-p-(dimethylamino)benzamide (21566-11-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1016/j.tetlet.2006.06.165

Reference yield: 65.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 4-dimethylamino-benzaldehyde (100-10-7) → N,N-dimethyl-p-(dimethylamino)benzamide (21566-11-0)

Guidance literature:

N,N-dimethyl-formamide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.25h; Schlenk technique;

4-dimethylamino-benzaldehyde; In tetrahydrofuran; at 50 ℃; for 12h;

DOI:10.1002/adsc.201500551

upstream raw materials:

4-(dimethylamino)benzoyl chloride

dimethyl amine

N,N-dimethyl-formamide dimethyl acetal

Dimethylamino-(4-dimethylamino-phenyl)-trimethylsilanyloxy-acetonitrile

Downstream raw materials:

4-dimethylamino[(dimethylamino)methyl]benzene

4-(dimethylamino)-N,N-dimethylbenzothioamide

(E)-1-(4-Dimethylamino-phenyl)-2,3-difluoro-3-phenyl-propenone

S-Methyl-N,N-dimethyl-p-dimethylamino-thiolbenzimidiumiodid