N,N-Dimethyl-4-(dimethylamino)benzenemethanamine

Base Information

• Chemical Name: N,N-Dimethyl-4-(dimethylamino)benzenemethanamine
• CAS No.: 51227-15-7
• Molecular Formula: C11H18N2
• Molecular Weight: 178.277
• Mol file: 51227-15-7.mol

Synonyms:N,N-Dimethyl-4-(dimethylamino)benzenemethanamine

Chemical Property of N,N-Dimethyl-4-(dimethylamino)benzenemethanamine

Chemical Property:

• Boiling Point: 67 °C (0.2 mmHg)
• PSA: 6.48000
• LogP: 1.81420

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-Dimethyl-4-(dimethylamino)benzenemethanamine

There total 7 articles about N,N-Dimethyl-4-(dimethylamino)benzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N,N-dimethyl-p-(dimethylamino)benzamide (21566-11-0) → 4-dimethylamino[(dimethylamino)methyl]benzene (51227-15-7)

Guidance literature:

With polymethylhydrosiloxane; dihydrogen hexachloroplatinate; In tetrahydrofuran; at 80 ℃; for 3h;

DOI:10.1016/j.tetlet.2006.06.165

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (4-aminomethylphenyl)dimethylamine (19293-58-4) → 4-dimethylamino[(dimethylamino)methyl]benzene (51227-15-7)

Guidance literature:

With hydrogen; In methanol; water; at 90 ℃; for 4h; under 15001.5 Torr; Autoclave; Green chemistry;

DOI:10.1039/d1gc00981h

Reference yield:

bis-(dimethylamino)methane (51-80-9) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → 4-dimethylamino[(dimethylamino)methyl]benzene (51227-15-7)

Guidance literature:

Multistep reaction; (i) AcCl, MeCN, CCl₄, (ii) /BRN= 507140/;

upstream raw materials:

hexamethylenetetramine

N,N-dimethyl-aniline

N,N-dimethyl-p-(dimethylamino)benzamide

4-(dimethylamino)-N,N-dimethylbenzothioamide

Downstream raw materials:

N-(N-Methyl-benzamidomethyl)-N-(4-dimethylaminobenzyl)-dimethylammoniumchlorid

N-(4-Dimethylaminobenzyl)-N-piperidinomethyl-dimethylammoniumchlorid

N-(4-Dimethylaminobenzyl)-N-(diethylaminomethyl)-dimethylammoniumchlorid

N-(4-Dimethylaminobenzyl)-N-morpholinomethyl-dimethylammoniumchlorid

Refernces

• 1、 Hanada, Shiori,Tsutsumi, Emi,Motoyama, Yukihiro,Nagashima, Hideo. "Practical access to amines by platinum-catalyzed reduction of carboxamides with hydrosilanes: Synergy of dual Si-H groups leads to high efficiency and selectivity". supporting information; experimental part. p. 15032 - 15040. Retrieved 2010/01/29.
• 2、 KNABE,SHUKLA. "The effect of chlorocarbonic acid ethyl ester on tertiary amines. 2. Effect of substitution in the aromatic ring of N-dimethylbenzylamines.". . p. 690 - 697. Retrieved 2007/10/04.