5-fluoro-2-aMinobenzophenone

Base Information

• Chemical Name: 5-fluoro-2-aMinobenzophenone
• CAS No.: 362-46-9
• Molecular Formula: C13H10FNO
• Molecular Weight: 215.227
• Hs Code.: 2922399090
• Mol file: 362-46-9.mol

Synonyms:3kr2;5-fluoro-2-aminobenzophenone;5-fluoro-2-aminobenzimidazole;2-amino-5-fluoro-benzophenone;2-Amino-5-fluor-benzophenon;2-AMINO-5-FLUOROBENZIMIDAZOLE;1H-Benzimidazol-2-amine,6-fluoro;5-FLUORO-1H-BENZIMIDAZOLE-2-AMINE;

Chemical Property of 5-fluoro-2-aMinobenzophenone

Chemical Property:

• Melting Point: 118 °C
• Boiling Point: 396.9±32.0 °C(Predicted)
• PKA: 0.75±0.10(Predicted)
• PSA: 43.09000
• Density: 1.236±0.06 g/cm3(Predicted)
• LogP: 3.22010
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-fluorobenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-fluoro-2-aMinobenzophenone

There total 14 articles about 5-fluoro-2-aMinobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-cyano-4-fluoroaniline (61272-77-3) + sodium benzenesulfonate (873-55-2) → 5-fluoro-2-aminobenzophenone (362-46-9)

Guidance literature:

With p-nitrobenzenesulfonic acid; palladium diacetate; In tetrahydrofuran; water; at 80 ℃; for 48h; Inert atmosphere; Schlenk technique;

DOI:10.3390/molecules19056439

Reference yield: 86.0%

C13H10FNO4S → 5-fluoro-2-aminobenzophenone (362-46-9)

Guidance literature:

With dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine; In 1,4-dioxane; at 25 ℃; for 8h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/chem.201903816

Reference yield: 85.0%

2-cyano-4-fluoroaniline (61272-77-3) + phenylboronic acid (98-80-6) → 5-fluoro-2-aminobenzophenone (362-46-9)

Guidance literature:

With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; water; In 2-methyltetrahydrofuran; at 80 ℃; for 36h; Schlenk technique;

DOI:10.1039/c4ob00978a

upstream raw materials:

benzonitrile

4-fluoroaniline

benzoyl chloride

(2-aminophenyl)(phenyl)methanone

Downstream raw materials:

2-amino-5-fluoro-3'-nitrobenzophenone

7-fluoro-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

Ro 05-4865

2-Bromacetylamino-5-fluor-benzophenon

Refernces

• 1、 Abdelkafi, Hajer,Michau, Aurélien,Pons, Valérie,Ngadjeua, Flora,Clerget, Alexandra,Ait Ouarab, Lilia,Buisson, David-Alexandre,Montoir, David,Caramelle, Lucie,Gillet, Daniel,Barbier, Julien,Cintrat, Jean-Christophe. "Structure-Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin". . p. 8114 - 8133. Retrieved 2020/09/21.
• 2、 Ruzi, Rehanguli,Ma, Junyang,Yuan, Xiang-Ai,Wang, Wenliang,Wang, Shanshan,Zhang, Muliang,Dai, Jie,Xie, Jin,Zhu, Chengjian. "Deoxygenative Arylation of Carboxylic Acids by Aryl Migration". . p. 12724 - 12729. Retrieved 2019/11/05.