1-phenyl-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid

Base Information

• Chemical Name: 1-phenyl-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid
• CAS No.: 362640-59-3
• Molecular Formula: C11H7F3N2O2
• Molecular Weight: 256.184
• Mol file: 362640-59-3.mol

Synonyms:1-phenyl-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid;2-Phenyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid;

Chemical Property of 1-phenyl-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid

Chemical Property:

• Boiling Point: 371.4±42.0 °C(Predicted)
• PKA: 2.44±0.10(Predicted)
• PSA: 55.12000
• Density: 1.44±0.1 g/cm3(Predicted)
• LogP: 2.58930
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-phenyl-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid

There total 11 articles about 1-phenyl-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester (81963-53-3) → 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid (362640-59-3)

Guidance literature:

With sodium hydroxide; In ethanol; at 21 ℃; for 1h;

DOI:10.1016/j.jfluchem.2018.07.010

Reference yield: 46.3%

C15H9F3N2O2 → 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid (362640-59-3)

Guidance literature:

C₁₅H₉F₃N₂O₂; With potassium permanganate; In acetone; at 60 ℃; for 3h;

In isopropyl alcohol; acetone; at 20 ℃;

DOI:10.1016/j.cclet.2016.02.009

Reference yield:

3-trifluoromethyl-5-(fur-2-yl)-1-phenyl-1H-pyrazole (515845-27-9) → 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid (362640-59-3)

Guidance literature:

With sodium hypochlorite; sodium chlorite; sodium dihydrogenphosphate; In acetonitrile;

DOI:10.1016/j.bmcl.2005.08.034

upstream raw materials:

5-methyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazole

3-trifluoromethyl-5-(fur-2-yl)-1-phenyl-1H-pyrazole

4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

1,1,1-Trifluoro-2,4-pentanedione

Downstream raw materials:

1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester

4-[5-(difluoromethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]aniline

4-[5-(fluoromethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]aniline

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