1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester
• CAS No.: 81963-53-3
• Molecular Formula: C₁₂H₉F₃N₂O₂
• Molecular Weight: 270.211

Synonyms:1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester

Chemical Property of 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester

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Technology Process of 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester

There total 8 articles about 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

2,4-dichloro-2-ethoxy-5,5,5-trifluoropentanoic acid methyl ester + phenylhydrazine (100-63-0) → 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester (81963-53-3)

Guidance literature:

With water; In toluene; at 20 - 30 ℃; for 1h;

Reference yield: 78.0%

2,4,4-trichloro-2-ethoxy-5,5,5-trifluoropentanoic acid methyl ester + phenylhydrazine (100-63-0) → 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester (81963-53-3)

Guidance literature:

With water; In toluene; at 20 - 30 ℃; for 1h;

Reference yield: 63.0%

2,2,2-trifluoromethylphenylhydrazine chloride (81963-43-1) + propynoic acid methyl ester (922-67-8) → Methyl 1-phenyl-3-trifluoromethylpyrazole-4-carboxylate (81963-54-4) + 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester (81963-53-3)

Guidance literature:

With triethylamine; In toluene; for 2h; Ambient temperature;

DOI:10.1246/cl.1982.543

upstream raw materials:

2,2,2-trifluoromethylphenylhydrazine chloride

propynoic acid methyl ester

bromure de N-phenyl trifluoroacetohydrazonoyle

phenylhydrazone of trifluoroacetaldehyde

Downstream raw materials:

methyl 1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate

1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carbaldehyde

5-(fluoromethyl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole

5-(difluoromethyl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole

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