81963-53-3

Upstream product

• 81963-43-1 2,2,2-trifluoromethylphenylhydrazine chloride 
• 922-67-8 propynoic acid methyl ester 
• 81963-44-2 bromure de N-phenyl trifluoroacetohydrazonoyle 
• 81963-42-0 phenylhydrazone of trifluoroacetaldehyde 
• 100-63-0 phenylhydrazine 
• 362640-59-3 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid 
• 67-56-1 methanol 
• 515845-27-9 3-trifluoromethyl-5-(fur-2-yl)-1-phenyl-1H-pyrazole 

Downstream Products

• 1288340-47-5 methyl 1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate 
• 1288340-48-6 1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carbaldehyde 
• 1288340-49-7 5-(fluoromethyl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole 
• 1288340-50-0 5-(difluoromethyl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole 
• 1288340-58-8 4-[5-(fluoromethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]aniline 
• 1288340-59-9 4-[5-(difluoromethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]aniline 
• 362640-59-3 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid 

Relevant academic research and scientific papers

Preparation methods for pyrazole compound

The invention discloses preparation methods for a pyrazole compound. The preparation methods include a method A and a method B. The method A comprises a step of subjecting a compound as shown in a formula (II-A) which is described in the specification and a compound as shown in a formula (III) which is described in the specification to a cyclization reaction in a solvent so as to obtain a compound as shown in a formula (I) which is described in the specification. The method B comprises a step of subjecting a compound as shown in a formula (II-B) which is described in the specification and the compound as shown in the formula (III) which is described in the specification to a cyclization reaction in a solvent so as to obtain the compound as shown in the formula (I) which is described in the specification. The preparation methods use cheap and easily available raw materials, are low in production cost, mild in reaction conditions, simple to operate, high in yield and purity of the target compound, green and environment-friendly, and more suitable for industrial production.

PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE -ACTIVATED CALCIUM CHANNEL

Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.

PREPARATION OF TRIFLUOROACETONITRILE PHENYLAMINE AND ITS REACTIONS WITH SOME DIPOLAROPHILES

Trifluoroaceto-N-phenylhydrazonoyl halides, the precursors of trifluoroacetonitrile phenylamine, prepared by halogenation of trifluoroacetaldehyde phenylhydrazon, react with various olefins and acetylenes in the presence of triethylamine to give 3-trifluo