515845-27-9

Basic information

• Product Name: 1H-Pyrazole, 5-(2-furanyl)-1-phenyl-3-(trifluoromethyl)-
• CAS NO: 515845-27-9
• Molecular Formula: C14H9F3N2O
• Molecular Weight: 278.233
• Mol File: 515845-27-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole, 5-(2-furanyl)-1-phenyl-3-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole, 5-(2-furanyl)-1-phenyl-3-(trifluoromethyl)-(515845-27-9)
• EPA Substance Registry System: 1H-Pyrazole, 5-(2-furanyl)-1-phenyl-3-(trifluoromethyl)-(515845-27-9)

Safety Data

• Hazardous Substances Data: 515845-27-9(Hazardous Substances Data)

Upstream product

• 326-90-9 4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione 
• 100-63-0 phenylhydrazine 
• 1214712-43-2 C₈H₄F₄O₂ 
• 588-64-7 (E)-1-benzylidene-2-phenylhydrazine 
• 1192-62-7 1-(2-furyl)-1-ethanone 
• 59-88-1 phenylhydrazine hydrochloride 
• 103-03-7 1-phenylsemicarbazide 

Downstream Products

• 1288340-59-9 4-[5-(difluoromethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]aniline 
• 1288340-58-8 4-[5-(fluoromethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]aniline 
• 1288340-50-0 5-(difluoromethyl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole 
• 1288340-49-7 5-(fluoromethyl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole 
• 1288340-48-6 1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carbaldehyde 
• 1288340-47-5 methyl 1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate 
• 81963-53-3 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester 
• 362640-60-6 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride 
• 362640-59-3 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid 

Relevant articles and documents

Synthesis, nematicidal activity and docking study of novel chromone derivatives containing substituted pyrazole

A series of chromone derivatives containing substituted pyrazole were designed and synthesized. Preliminary bioassays showed that most of the synthesized compounds exhibited good nematicidal activity in vivo against Meloidogyne incognita at 10 mg/L. Among the tested compounds, A10 and A11 exhibited 100% inhibition rates. In addition, the molecular docking results indicated that both compound A10 and A11 interacts with amino acid residue Tyr121, Trp279, Tyr70, Trp84 and Phe330 of AChE via hydrogen bond and π–π stacking. This investigation suggested that the chromone containing substituted pyrazole scaffold could be further optimized to explore novel, high-bioactivity nematicidal leads.

New one-pot, efficient, and regioselective method for the synthesis of 3-Trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs

An efficient and regioselective procedure for the synthesis of a series of alkyl(aryl/heteroaryl) substituted 3-trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs, from the cyclocondensation reactions of 4-alkoxy-1,1,1-trihaloalk-3-en-2-ones [CX3C(O)CR2=CR 1(OMe/OEt), where R1 = H, Me, Ph, 2-Furyl; R2 = H; R1-R2 = -C4H8- and X = F, Cl] and 1-phenylsemicarbazide in an acidified alcoholic medium (R 3OH/H2SO4), where R3 = Me, Et, Pri was successfully applied and is described here in detail. 2012 Elsevier Ltd. All rights reserved.

Regioselective synthesis of trifluoromethyl group substituted pyrazole derivatives from 1-aryl-3,4,4,4-tetrafluoro-2-buten-1-ones

Trifluoromethyl group substituted pyrazole derivatives were prepared from hydrazines and 1-aryl-3,4,4,4-tetrafluoro-2-buten-1-ones obtained by the deoxyfluorination of β-diketones. The reaction proceeded regioselectively and 5-aryl-3-trifluoromethyl-1-phe