Propanoic acid, 2-methyl-, 3-methylphenyl ester

Base Information

• Chemical Name: Propanoic acid, 2-methyl-, 3-methylphenyl ester
• CAS No.: 36438-55-8
• Molecular Formula: C11H14O2
• Molecular Weight: 178.22800
• Mol file: 36438-55-8.mol

Synonyms:m-Kreyl-isobutyrate;m-Tolylisobutyrate;isobutyric acid m-tolyl ester;Isobuttersaeure-m-tolylester;m-tolyl isobutyrate;

Chemical Property of Propanoic acid, 2-methyl-, 3-methylphenyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 2.55640

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 2-methyl-, 3-methylphenyl ester

There total 5 articles about Propanoic acid, 2-methyl-, 3-methylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

trimethylsilyl isobutyrate (16883-61-7) + (3-methylphenoxy)trimethylsilane (17902-31-7) → 3-methylphenyl 2-methylpropionate (36438-55-8)

Guidance literature:

With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride; In dichloromethane; for 6h; Ambient temperature;

DOI:10.1246/bcsj.66.1516

Reference yield: 52.0%

3-methyl-phenol (108-39-4) + isobutyric Acid (79-31-2) → 3-methylphenyl 2-methylpropionate (36438-55-8) + 1-(4-hydroxy-2-methylphenyl)-2-methylpropan-1-one (761459-40-9) + 1-(2-hydroxy-4-methylphenyl)-2-methylpropan-1-one (116557-45-0)

Guidance literature:

With phosphorus pentoxide; silica gel; at 100 ℃; for 24h;

Reference yield: 18.9%

3-methyl-phenol (108-39-4) + isobutyric Acid (79-31-2) → 3-methylphenyl 2-methylpropionate (36438-55-8)

Guidance literature:

With Porcine Pancreas Lipase; at 50 - 60 ℃; for 69h;

upstream raw materials:

3-methyl-phenol

isobutyric Acid

trimethylsilyl isobutyrate

(3-methylphenoxy)trimethylsilane

Downstream raw materials:

1-(2-hydroxy-4-methylphenyl)-2-methylpropan-1-one