4-METHYL-2-PHENYLBENZIMIDAZOLE

Base Information

• Chemical Name: 4-METHYL-2-PHENYLBENZIMIDAZOLE
• CAS No.: 3659-77-6
• Molecular Formula: C14H12N2
• Molecular Weight: 208.263
• Mol file: 3659-77-6.mol

Synonyms:2-Phenyl-7-methylbenzimidazol;7-methyl-2-phenyl-1H-benzo[d]imidazole;7-methyl-2-phenyl-1H-benzimidazole;7-methyl-2-phenylbenzimidazole;7-Methyl-2-phenyl-1H-benzoimidazole;4-methyl-2-phenyl-1(3)H-benzoimidazole;7-methyl-2-phenyl-benzimidazole;

Chemical Property of 4-METHYL-2-PHENYLBENZIMIDAZOLE

Chemical Property:

• PSA: 28.68000
• LogP: 3.53830

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYL-2-PHENYLBENZIMIDAZOLE

There total 42 articles about 4-METHYL-2-PHENYLBENZIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Methyl-6-nitroaniline (570-24-1) + benzaldehyde (100-52-7) → 4-methyl-2-phenyl-1H-benzimidazole (3659-77-6)

Guidance literature:

With hydrogen; In ethyl acetate; at 60 ℃; for 20h; under 7500.75 Torr; Autoclave; Green chemistry;

DOI:10.1002/cssc.202002344

Reference yield: 98.0%

benzaldehyde (100-52-7) + 3-methyl-1,2-benzenediamine (2687-25-4) → 7-methyl-2-phenyl-1H-benzo[d]imidazole (3659-77-6)

Guidance literature:

With acetic acid; In neat (no solvent); at 25 ℃; for 0.166667h;

Reference yield: 98.0%

iodobenzene (591-50-4) + carbon monoxide (201230-82-2) + 3-methyl-1,2-benzenediamine (2687-25-4) → 4-methyl-2-phenyl-1H-benzimidazole (3659-77-6)

Guidance literature:

With 2,6-dimethylpyridine; bis(triphenylphosphine)palladium(II)-chloride; In N,N-dimethyl acetamide; at 140 ℃; for 24h; under 4912.9 Torr;

DOI:10.1021/jo00077a019

upstream raw materials:

N-(2-methyl-6-nitrophenyl)benzamide

N-o-tolyl-benzamide oxime

benzenesulfonyl chloride

N-(o-tolyl)benzimidamide

Downstream raw materials:

11-methyl-6-phenylbenzo[4,5]imidazo[2,1-a]isoquinoline

C₁₄H₁₀N₂O

C₁₉H₂₁N₃