(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
CAS No.:365997-33-7
Molecular Formula:C14H25NO5
Molecular Weight:287.356
Hs Code.:
Mol file:365997-33-7.mol

Synonyms:(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxycyclohexanecarboxylic acid ethyl ester;ethyl (1S,3R,4R)-3-[(t-butoxycarbonyl)amino]-4-hydroxycyclohexanecarboxylate;Ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate;ethyl (1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxycyclohexanecarboxylate;

Suppliers and Price of (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl(1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate
2.5g
$ 60.00

Matrix Scientific
(1S,3R,4R)-3-(Boc-amino)-4-hydroxy-cyclohexanecarboxylicacidethylester 97.0%
1g
$ 1073.00

Crysdot
(1S,3R,4R)-Ethyl3-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexanecarboxylate 95+%
1g
$ 668.00

Chemenu
(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylicacidethylester 97%
100g
$ 418.00

American Custom Chemicals Corporation
(1S,3R,4R)-3-(BOC-AMINO)-4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER 95.00%
5MG
$ 499.94

Ambeed
(1S,3R,4R)-Ethyl3-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexanecarboxylate 97+%
5g
$ 29.00

Ambeed
(1S,3R,4R)-Ethyl3-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexanecarboxylate 97+%
100g
$ 176.00

Ambeed
(1S,3R,4R)-Ethyl3-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexanecarboxylate 97+%
25g
$ 90.00

AK Scientific
(1S,3R,4R)-3-(Boc-amino)-4-hydroxy-cyclohexanecarboxylicacidethylester
100g
$ 691.00

AK Scientific
(1S,3R,4R)-3-(Boc-amino)-4-hydroxy-cyclohexanecarboxylicacidethylester
10g
$ 184.00

Total 47 raw suppliers

Chemical Property of (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester

Chemical Property:

Melting Point:93-95°C
Boiling Point:406.6±45.0 °C(Predicted)
PKA:11.73±0.60(Predicted)
PSA：84.86000
Density:1.12±0.1 g/cm3(Predicted)
LogP:1.99470
Storage Temp.:Refrigerator
Solubility.:Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Ethyl(1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate, is a building block used in various chemicla synthesis. It can be used for the preparation of six stereoisomers of diaminocyclohexane carboxamide as key intermediates for synthesis of factor Xa inhibitors.

Technology Process of (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester

There total 15 articles about (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 365997-31-5
(1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylic acid ethyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 365997-33-7
ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate

Guidance literature:: (1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylic acid ethyl ester; With ammonia; In water; at 45 ℃;

di-tert-butyl dicarbonate; In ethanol; at 20 ℃;
DOI:10.1016/j.bmcl.2020.126969

Reference yield: 9.8%

: 365997-32-6
ethyl (1S,3R,4R)-3-azido-4-hydroxycyclohexane-1-carboxylate

: 24424-99-5
di-tert-butyl dicarbonate

: 365997-33-7
ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; at 20 ℃; under 5149.01 Torr;
DOI:10.1016/j.bmc.2008.12.037

Reference yield:

: 636-82-8
cyclohexene-1-carboxylic acid

: 365997-33-7
ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate; potassium iodide / dichloromethane / 0.17 h

1.2: 2 h / 20 °C

2.1: 0.17 h / 20 °C

2.2: 3 h

3.1: ammonium hydroxide / ethanol / 4 h / 40 °C

4.1: potassium carbonate / ethyl acetate / 5 h / 20 °C

5.1: vinyl acetate / di-isopropyl ether / 18 h / 45 °C / Enzymatic reaction

With ammonium hydroxide; vinyl acetate; sodium hydrogencarbonate; potassium carbonate; potassium iodide; In ethanol; dichloromethane; di-isopropyl ether; ethyl acetate;