(1s,3r,4r)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1s,3r,4r)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester
CAS No.:365997-36-0
Molecular Formula:C₁₅H₂₇NO₇S
Molecular Weight:365.448
Hs Code.:
Mol file:365997-36-0.mol

Synonyms:(1s,3r,4r)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester;(1S,3R,4R)-Ethyl 3-((tert-butoxycarbonyl)amino)-4-((methylsulfonyl)oxy)cyclohexanecarboxylate;ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-(methanesulfonyloxy)cyclohexane-1-carboxylate;Cyclohexanecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[(methylsulfonyl)oxy]-, ethyl ester, (1S,3R,4R)-

Suppliers and Price of (1s,3r,4r)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1s,3r,4r)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (1s,3r,4r)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester

There total 8 articles about (1s,3r,4r)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 365997-33-7
ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate

: 124-63-0
methanesulfonyl chloride

: 365997-36-0
(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester

Guidance literature:: With triethylamine; In ethyl acetate; at 20 ℃; for 1h;

Reference yield:

: 365997-31-5
(1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylic acid ethyl ester

: 365997-36-0
(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide / water; ethanol / 45 °C

2: ammonium hydroxide / ethanol / 20 °C / Cooling with ice

3: triethylamine / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

With ammonium hydroxide; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2017.01.021

Reference yield:

: 5708-19-0
(1S)-3-cyclohexenecarboxylic acid

: 365997-36-0
(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate; iodine; potassium iodide / water / 5 h / 20 °C

2: sodium hydroxide / water

3: ammonium hydroxide / water; ethanol / 45 °C

4: ammonium hydroxide / ethanol / 20 °C / Cooling with ice

5: triethylamine / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

With ammonium hydroxide; iodine; sodium hydrogencarbonate; triethylamine; potassium iodide; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2017.01.021