2-tert-butyl 5-methyl isoindoline-2,5-dicarboxylate

Base Information

• Chemical Name: 2-tert-butyl 5-methyl isoindoline-2,5-dicarboxylate
• CAS No.: 368441-44-5
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.31600
• Mol file: 368441-44-5.mol

Synonyms:2H-Isoindole-2,5-dicarboxylic acid,1,3-dihydro-,2-(1,1-dimethylethyl) 5-methyl ester;2-tert-butyl 5-methyl isoindoline-2,5-dicarboxylate;N-t-butoxycarbonyl-5-methoxycarbonylisoindoline;methyl 2-tert-butoxycarbonylisoindoline-5-carboxylate;1,3-dihydro-isoindole-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester;

Chemical Property of 2-tert-butyl 5-methyl isoindoline-2,5-dicarboxylate

Chemical Property:

• PSA: 55.84000
• Density: 1.181
• LogP: 2.66180

Purity/Quality:

97% ^*data from raw suppliers

2-tert-Butyl5-methylisoindoline-2,5-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-tert-butyl 5-methyl isoindoline-2,5-dicarboxylate

There total 9 articles about 2-tert-butyl 5-methyl isoindoline-2,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

5-bromo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (201940-08-1) → 2-(tert-butyl) 5-methyl isoindoline-2,5-dicarboxylate (368441-44-5)

Guidance literature:

With triethanolamine; palladium diacetate; In methanol; dimethyl sulfoxide;

Reference yield: 81.0%

5-bromo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (201940-08-1) + carbon monoxide (201230-82-2) → 2-(tert-butyl) 5-methyl isoindoline-2,5-dicarboxylate (368441-44-5)

Guidance literature:

With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine; In methanol; dimethyl sulfoxide; at 80 ℃; for 16h;

Reference yield: 72.0%

5-bromo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (201940-08-1) + methanol (67-56-1) + carbon monoxide (201230-82-2) → 2-(tert-butyl) 5-methyl isoindoline-2,5-dicarboxylate (368441-44-5)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1021/acs.jmedchem.9b00365

upstream raw materials:

5-bromo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

methyl 2,3-dihydro-2-(phenylmethyl)-1H-isoindole-5-carboxylate

di-tert-butyl oxalate

carbon monoxide

Downstream raw materials:

methyl isoindoline-5-carboxylate

tert-butyl 5-(hydroxymethyl)-1,3-dihydro-2H-isoindole-2-carboxylate

5-formyl-1,2-dihydro-isoindole-2-carboxylic acid tertiary butyl ester

2-(tert-butoxycarbonyl)isoindoline-5-carboxylic acid