3-(2-Phenylethyl)pyridine

Base Information

• Chemical Name: 3-(2-Phenylethyl)pyridine
• CAS No.: 6312-09-0
• Molecular Formula: C13H13 N
• Molecular Weight: 183.253
• NSC Number: 42667
• DSSTox Substance ID: DTXSID80285712
• Nikkaji Number: J370.649D
• Wikidata: Q72501844
• ChEMBL ID: CHEMBL1879702
• Mol file: 6312-09-0.mol

Synonyms:Pyridine,3-phenethyl- (8CI); 1-Phenyl-2-(b-pyridyl)ethane; 3-Phenethylpyridine; NSC 42667

Chemical Property of 3-(2-Phenylethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.00592mmHg at 25°C
• Boiling Point: 281.9oC at 760 mmHg
• Flash Point: 115.3oC
• PSA: 12.89000
• Density: 1.04g/cm3
• LogP: 2.86680
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 183.104799419
• Heavy Atom Count: 14
• Complexity: 149

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-PHENYLETHYL)PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCC2=CN=CC=C2

Technology Process of 3-(2-Phenylethyl)pyridine

There total 38 articles about 3-(2-Phenylethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-3-(2-phenylvinyl)pyridine (2633-06-9) → 3-(2-phenylethyl)pyridine (6312-09-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00145a006

Reference yield: 86.0%

3-iodopyridine (1120-90-7) + 2-phenethyl iodide (17376-04-4) → 3-(2-phenylethyl)pyridine (6312-09-0)

Guidance literature:

2-phenethyl iodide; With indium; copper(ll) sulfate pentahydrate; In tetrahydrofuran; water; at 60 ℃; for 12h;

3-iodopyridine; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; In N,N-dimethyl acetamide; water; at 80 ℃; for 24h;

DOI:10.1016/j.tetlet.2019.151288

Reference yield: 72.0%

3-pyridinylethanol (6293-56-7) + bromobenzene (108-86-1,52753-63-6) → 3-(2-phenylethyl)pyridine (6312-09-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; triphenylphosphine; 4,4'-di-tert-butyl-2,2'-bipyridine; lithium bromide; nickel dibromide; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 14h; Glovebox; Electrolysis;

DOI:10.1021/jacs.0c13093

upstream raw materials:

1-phenyl-2-(pyridin-3-yl)ethanone

2-phenyl-1-(pyridin-3-yl)ethanone

3-Methylpyridine

benzyl alcohol

Downstream raw materials:

3-phenethylpiperidine

2-amino-5-(2-phenylethyl)pyridine

2-amino-3-(2-phenylethyl)pyridine

2-methyl-8-(2-phenylethyl)imidazo[1,2-a]pyridine-3-acetonitrile

Refernces

• 1、 Chinchole, Anurag N.,Dubey, Abhishek V.,Kumar, A. Vijay. "Bioinspired Palladium Nanoparticles Supported on Soil-Derived Humic Acid Coated Iron-Oxide Nanoparticles as Catalyst for C–C Cross-Coupling and Reduction Reactions". . p. 1224 - 1236. Retrieved 2019/02/26.
• 2、 Wang, Peng,Song, Xuan-Di,Chen, Bing-Zhi,Rao, Weidong,Shen, Zhi-Liang. "Cobalt(II)-catalyzed preparation of alkylindium reagents and applications in cross-coupling with aryl halides". . . Retrieved 2019/10/16.