Methanone, [4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)- 1-pyrrolidinyl]-5-pyrimidinyl](1-methyl-1H-imidazol-2-yl)-

Base Information

Chemical Name:Methanone, [4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)- 1-pyrrolidinyl]-5-pyrimidinyl](1-methyl-1H-imidazol-2-yl)-
CAS No.:372113-71-8
Molecular Formula:C22H25ClN6O3
Molecular Weight:456.932
Hs Code.:
Mol file:372113-71-8.mol

Methanone,
[4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-
1-pyrrolidinyl]-5-pyrimidinyl](1-methyl-1H-imidazol-2-yl)-

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Chemical Property of Methanone, [4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)- 1-pyrrolidinyl]-5-pyrimidinyl](1-methyl-1H-imidazol-2-yl)-

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Technology Process of Methanone, [4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)- 1-pyrrolidinyl]-5-pyrimidinyl](1-methyl-1H-imidazol-2-yl)-

There total 7 articles about Methanone, [4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)- 1-pyrrolidinyl]-5-pyrimidinyl](1-methyl-1H-imidazol-2-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 372113-70-7
[4-(3-Chloro-4-methoxy-benzylamino)-2-methylsulfanyl-pyrimidin-5-yl]-(1-methyl-1H-imidazol-2-yl)-methanone

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 372113-71-8
(S)-4-(3-chloro-4-methoxybenzylamino)-2-(2-hydroxymethyl-1-pyrrolidinyl)5-(1-methyl-2-imidazolylcarbonyl)pyrimidine

Guidance literature:: [4-(3-Chloro-4-methoxy-benzylamino)-2-methylsulfanyl-pyrimidin-5-yl]-(1-methyl-1H-imidazol-2-yl)-methanone; With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 0 ℃;

(S)-1-Pyrrolidin-2-yl-methanol; With triethylamine; In chloroform; at 20 ℃;
DOI:10.1016/j.bmcl.2015.02.041

Reference yield:

: 330785-81-4
ethyl 4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylate

: 372113-71-8
(S)-4-(3-chloro-4-methoxybenzylamino)-2-(2-hydroxymethyl-1-pyrrolidinyl)5-(1-methyl-2-imidazolylcarbonyl)pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: n-butyllithium / tetrahydrofuran / -78 °C

3.2: 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0 °C

4.2: 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1016/j.bmcl.2015.02.041

Reference yield:

: 115514-77-7
(3-chloro-4-methoxyphenyl)methanamine

: 372113-71-8
(S)-4-(3-chloro-4-methoxybenzylamino)-2-(2-hydroxymethyl-1-pyrrolidinyl)5-(1-methyl-2-imidazolylcarbonyl)pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

3.1: manganese(IV) oxide / dichloromethane / 20 °C

4.1: n-butyllithium / tetrahydrofuran / -78 °C

4.2: 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0 °C

5.2: 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1016/j.bmcl.2015.02.041