Methanone, [4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(methylthio)-5-pyrimidin yl](1-methyl-1H-imidazol-2-yl)-

Base Information

Chemical Name:Methanone, [4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(methylthio)-5-pyrimidin yl](1-methyl-1H-imidazol-2-yl)-
CAS No.:372113-70-7
Molecular Formula:C18H18ClN5O2S
Molecular Weight:403.892
Hs Code.:
Mol file:372113-70-7.mol

Synonyms:

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Chemical Property of Methanone, [4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(methylthio)-5-pyrimidin yl](1-methyl-1H-imidazol-2-yl)-

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Technology Process of Methanone, [4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(methylthio)-5-pyrimidin yl](1-methyl-1H-imidazol-2-yl)-

There total 6 articles about Methanone, [4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(methylthio)-5-pyrimidin yl](1-methyl-1H-imidazol-2-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 616-47-7
1-methyl-1H-imidazole

: 330785-86-9
4-(3-Chloro-4-methoxy-benzylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde

: 372113-70-7
[4-(3-Chloro-4-methoxy-benzylamino)-2-methylsulfanyl-pyrimidin-5-yl]-(1-methyl-1H-imidazol-2-yl)-methanone

Guidance literature:: 1-methyl-1H-imidazole; 4-(3-Chloro-4-methoxy-benzylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

With manganese(IV) oxide; In tetrahydrofuran; chloroform; at 20 ℃;
DOI:10.1016/j.bmcl.2015.02.041

Reference yield:

: 454486-92-1
[4-(3-Chloro-4-methoxy-benzylamino)-2-methylsulfanyl-pyrimidin-5-yl]-(1-methyl-1H-imidazol-2-yl)-methanol

: 372113-70-7
[4-(3-Chloro-4-methoxy-benzylamino)-2-methylsulfanyl-pyrimidin-5-yl]-(1-methyl-1H-imidazol-2-yl)-methanone

Guidance literature:: With manganese dioxide; In chloroform; at 20 ℃; for 72h;

Reference yield:

: 330785-81-4
ethyl 4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylate

: 372113-70-7
[4-(3-Chloro-4-methoxy-benzylamino)-2-methylsulfanyl-pyrimidin-5-yl]-(1-methyl-1H-imidazol-2-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: n-butyllithium / tetrahydrofuran / -78 °C

3.2: 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2015.02.041