4(1H)-Quinolinone, 2-(4-methoxyphenyl)-

Base Information

• Chemical Name: 4(1H)-Quinolinone, 2-(4-methoxyphenyl)-
• CAS No.: 3813-92-1
• Molecular Formula: C16H13NO2
• Molecular Weight: 251.285
• Mol file: 3813-92-1.mol

Synonyms:2-(4-methoxyphenyl)-quinolin-4(1H)-one;2-(p-methoxyphenyl)-quinolin-4(1H)-one;2-(4-Methoxy-phenyl)-1H-quinolin-4-one;2-(4-methoxyphenyl)-4-quinolone;2-(4-methoxyphenyl)-1H-quinolin-4-one;2-(4-methoxyphenyl)quinolin-4(1H)-one;

Chemical Property of 4(1H)-Quinolinone, 2-(4-methoxyphenyl)-

Chemical Property:

• Melting Point: 176 - 177 °C (acetone)
• Boiling Point: 418.7±45.0 °C(Predicted)
• PSA: 42.09000
• Density: 1.206±0.06 g/cm3(Predicted)
• LogP: 3.20370

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4(1H)-Quinolinone, 2-(4-methoxyphenyl)-

There total 41 articles about 4(1H)-Quinolinone, 2-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(2-acetyl-phenyl)-4-methoxy-benzamide (33768-41-1) → 2-(4-methoxyphenyl)-1,4-dihydro-4-oxoquinoline (3813-92-1)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 110 ℃; for 2h; Sealed tube; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.11.093

Reference yield: 95.0%

carbon monoxide (201230-82-2) + 2-iodophenylamine (615-43-0) + 4-methoxyphenylacetylen (768-60-5) → 2-(4-methoxyphenyl)-1,4-dihydro-4-oxoquinoline (3813-92-1)

Guidance literature:

With diethylamine; bis-triphenylphosphine-palladium(II) chloride; at 120 ℃; for 6h; Pressure (range begins): 20 ;

DOI:10.1016/0040-4039(91)80864-3

Reference yield: 95.0%

1-(2-aminophenyl)-3-(4-methoxyphenyl)prop-2-yn-1-one (1200055-82-8) → 2-(4-methoxyphenyl)-1,4-dihydro-4-oxoquinoline (3813-92-1)

Guidance literature:

With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); In acetonitrile; at 20 ℃; for 24h;

DOI:10.1002/ejoc.201402224

upstream raw materials:

2-(4-methoxyphenyl)-2,3-dihydroquinolin-4(1H)-one

carbon monoxide

2-iodophenylamine

4-methoxyphenylacetylen

Downstream raw materials:

3-iodo-2-(4'-methoxyphenyl)-quinolin-4(1H)-one

3-bromo-2-(4'-methoxyphenyl)quinolin-4(1H)-one

3-iodo-2-(4'-methoxyphenyl)-1-methylquinolin-4(1H)-one

4-chloro-3-bromo-2-(4-methoxyphenyl)quinoline