2-Amino-4-hydroxybenzoic acid

Base Information

• Chemical Name: 2-Amino-4-hydroxybenzoic acid
• CAS No.: 38160-63-3
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.137
• Hs Code.: 2922500090
• European Community (EC) Number: 862-417-1
• DSSTox Substance ID: DTXSID90457862
• Nikkaji Number: J89.208D
• Wikidata: Q82280895
• Mol file: 38160-63-3.mol

Synonyms:2-amino-4-hydroxybenzoic acid;38160-63-3;2-amino-4-hydroxy-benzoic Acid;Benzoic acid, 2-amino-4-hydroxy-;4-Hydroxyanthanilic acid;2-Amino-4-oxybenzoesaure;2-amino-4-hydroxybenzoicacid;SCHEMBL440293;Benzoicacid,2-amino-4-hydroxy-;DTXSID90457862;MFCD00071506;AKOS015890791;Benzoic acid, 2-amino-4-hydroxy-;MB00542;AS-42652;CS-0096257;FT-0710653;EN300-151217;A904993

Chemical Property of 2-Amino-4-hydroxybenzoic acid

Chemical Property:

• Vapor Pressure: 5.03E-07mmHg at 25°C
• Melting Point: 158 °C (decomp)
• Boiling Point: 397.3±32.0 °C(Predicted)
• PKA: 5.31±0.10(Predicted)
• Density: 1.491±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 153.042593085
• Heavy Atom Count: 11
• Complexity: 160

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-4-hydroxybenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1O)N)C(=O)O

Technology Process of 2-Amino-4-hydroxybenzoic acid

There total 5 articles about 2-Amino-4-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.2%

4-hydroxy-2-nitrobenzoic acid (74230-08-3) → 4-hydroxyanthranilic acid (38160-63-3)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; for 3h;

DOI:10.1016/0031-9422(95)00805-5

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + cesium m-aminophenoxide → 4-Aminosalicylic acid (65-49-6) + 4-hydroxyanthranilic acid (38160-63-3)

Guidance literature:

at 250 ℃; for 1h; under 37503 Torr;

DOI:10.1246/bcsj.76.2191

Reference yield:

4-amino-2-nitrobenzoic acid (610-36-6) → 4-hydroxyanthranilic acid (38160-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaNO₂, 2.) H₂O

2: 58.2 percent / H₂ / PtO₂ / ethanol / 3 h

With water; hydrogen; sodium nitrite; platinum(IV) oxide; In ethanol;

DOI:10.1016/0031-9422(95)00805-5

upstream raw materials:

4-hydroxy-2-nitrobenzoic acid

carbon dioxide

4-amino-2-nitrobenzoic acid

2,4-dinitrobenzoic acid

Downstream raw materials:

4-amino-6-hydroxyisophthalic acid

acide hydroxy-4 N-benzoyl anthranilique

2-phenyl-7-benzoyloxy-4H-3,1-benzoxazin-4-one

(E)-5-hydroxy-2-[[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid