74230-08-3

Basic information

• Product Name: 4-hydroxy-2-nitrobenzoic acid
• Synonyms: 4-hydroxy-2-nitrobenzoic acid;BENZOIC ACID, 4-HYDROXY-2-NITRO-
• CAS NO: 74230-08-3
• Molecular Formula: C₇H₅NO₅
• Molecular Weight: 183.1183
• Mol File: 74230-08-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 230 ºC (DEC.)
• Boiling Point: 414 °C at 760 mmHg
• Flash Point: 190.8 °C
• Appearance: /
• Density: 1.631
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.55±0.25(Predicted)
• CAS DataBase Reference: 4-hydroxy-2-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-2-nitrobenzoic acid(74230-08-3)
• EPA Substance Registry System: 4-hydroxy-2-nitrobenzoic acid(74230-08-3)

Safety Data

• Hazardous Substances Data: 74230-08-3(Hazardous Substances Data)

Usage

General Description

4-hydroxy-2-nitrobenzoic acid, also known as 2-nitro-4-hydroxybenzoic acid, is a compound with the molecular formula C7H5NO5. It is a derivative of benzoic acid, containing a hydroxyl group and a nitro group at the 4 and 2 positions, respectively. 4-hydroxy-2-nitrobenzoic acid is commonly used as a building block in the synthesis of pharmaceuticals and dyes. It also has potential applications in the field of organic chemistry, particularly in the development of new synthetic methods and strategies. Additionally, 4-hydroxy-2-nitrobenzoic acid has been studied for its potential antioxidant and antimicrobial properties, making it a subject of interest in the fields of medicine and food science.

Upstream product

• 610-36-6 4-amino-2-nitrobenzoic acid 
• 244765-00-2 N-Boc-5-hydroxyanthranilic acid 
• 33844-21-2 2-nitro-4-methoxybenzoic acid 
• 619-57-8 p-hydroxybenzamide 

Downstream Products

• 401568-70-5 methyl 2-amino-4-hydroxybenzoate 
• 19013-10-6 ethyl 4-hydroxy-3-nitrobenzoate 
• 104356-27-6 ethyl 4-hydroxy-2-nitrobenzoate 
• 38160-63-3 4-hydroxyanthranilic acid 
• 178758-50-4 methyl 4-hydroxy-2-nitrobenzoate 

Relevant articles and documents

METHOD FOR SPECIFIC CLEAVAGE OF C Alpha-C BOND AND SIDE CHAIN OF PROTEIN AND PEPTIDE, AND METHOD FOR DETERMINING AMINO ACID SEQUENCE

The present invention provides a method for specifically cleaving a Cα-C bond of a peptide backbone and/or a side chain of a protein and a peptide, and a method for determining amino acid sequences of protein and peptide. A method for specifically cleaving a Cα-C bond of a peptide backbone and/or a side chain bond of a protein or a peptide, comprising irradiating a protein or a peptide with laser light in the presence of at least one hydroxynitrobenzoic acid selected from the group consisting of 3-hydroxy-2-nitrobenzoic acid, 4-hydroxy-3-nitrobenzoic acid, 5-hydroxy-2-nitrobenzoic acid, 3-hydroxy-5-nitrobenzoic acid, and 4-hydroxy-2-nitrobenzoic acid. A method for determining an amino acid sequence of a protein or a peptide, comprising irradiating a protein or a peptide with laser light in the presence of the above specific hydroxynitrobenzoic acid to specifically cleave a Cα-C bond of a peptide backbone and/or a side chain bond, and analyzing generated fragment ions by mass spectrometry.

Amyl nitrite-mediated conversion of aromatic and heteroaromatic primary amides to carboxylic acids

A series of aromatic and heteroaromatic primary amides were converted directly to carboxylic acids by heating with amyl nitrite in acetic acid. Most conversions proceeded to give reasonable to excellent yields on a range of substrates containing various functional groups. This reagent system is thus applicable for the direct hydrolysis of a range of different primary carboxamides. The reaction with a phenolic aromatic substrate afforded two alternative nitration products as major outcomes, evidencing alternative reaction pathways resulting from the free phenolic OH.

Substituted aryloximes

The present invention relates to substituted aryl oximes and methods of using them.