Thiomorpholine, 4-(2,6-difluoro-4-nitrophenyl)-, 1,1-dioxide

Base Information

Chemical Name:Thiomorpholine, 4-(2,6-difluoro-4-nitrophenyl)-, 1,1-dioxide
CAS No.:383199-90-4
Molecular Formula:C10H10F2N2O4S
Molecular Weight:292.263
Hs Code.:
DSSTox Substance ID:DTXSID40432881
Wikidata:Q82247004

Synonyms:383199-90-4;THIOMORPHOLINE, 4-(2,6-DIFLUORO-4-NITROPHENYL)-, 1,1-DIOXIDE;SCHEMBL3042418;4-(2,6-difluoro-4-nitrophenyl)thiomorpholine 1,1-dioxide;DTXSID40432881;BQHWIHSGWDPFRE-UHFFFAOYSA-N

Suppliers and Price of Thiomorpholine, 4-(2,6-difluoro-4-nitrophenyl)-, 1,1-dioxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Thiomorpholine, 4-(2,6-difluoro-4-nitrophenyl)-, 1,1-dioxide

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:292.03293430
Heavy Atom Count:19
Complexity:421

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CS(=O)(=O)CCN1C2=C(C=C(C=C2F)[N+](=O)[O-])F

Technology Process of Thiomorpholine, 4-(2,6-difluoro-4-nitrophenyl)-, 1,1-dioxide

There total 2 articles about Thiomorpholine, 4-(2,6-difluoro-4-nitrophenyl)-, 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.4%

: 383199-89-1
4-(2,6-difluorophenyl)thiomorpholine 1,1-dioxide

: 383199-90-4
4-(2,6-difluoro-4-nitrophenyl)thiomorpholine-1,1-dioxide

Guidance literature:: With nitric acid; acetic acid; at 20 - 30 ℃; for 48h; regioselective reaction; Large scale;
DOI:10.1021/op050207i

Reference yield:

: 5509-65-9
2,6-difluoroaniline

: 383199-90-4
4-(2,6-difluoro-4-nitrophenyl)thiomorpholine-1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride / toluene / 24 h / 110 °C / Large scale

2: nitric acid; acetic acid / 48 h / 20 - 30 °C / Large scale

With aluminum (III) chloride; nitric acid; acetic acid; In toluene; 1: |Michael Addition;
DOI:10.1021/op050207i