2,4-Diphenyl-5-methyloxazole

Base Information

• Chemical Name: 2,4-Diphenyl-5-methyloxazole
• CAS No.: 38511-88-5
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• European Community (EC) Number: 661-557-9
• DSSTox Substance ID: DTXSID60401670
• Nikkaji Number: J1.384.764I
• Wikidata: Q82204882
• Mol file: 38511-88-5.mol

Synonyms:38511-88-5;5-Methyl-2,4-diphenyloxazole;2,4-Diphenyl-5-methyloxazole;Oxazole, 5-methyl-2,4-diphenyl-;SCHEMBL2089931;DTXSID60401670;AKOS024325095

Chemical Property of 2,4-Diphenyl-5-methyloxazole

Chemical Property:

• PSA: 26.03000
• LogP: 4.31700
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 235.099714038
• Heavy Atom Count: 18
• Complexity: 256

Purity/Quality:

2,4-DIPHENYL-5-METHYLOXAZOLE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=C(O1)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 2,4-Diphenyl-5-methyloxazole

There total 31 articles about 2,4-Diphenyl-5-methyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-methyl-2-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxazole (885669-17-0) + bromobenzene (108-86-1,52753-63-6) → 2,4-diphenyl-5-methyloxazole (38511-88-5)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

DOI:10.1055/s-2006-932471

Reference yield: 85.0%

benzonitrile (100-47-0) + 1-phenyl-propan-1-one (93-55-0) → 2,4-diphenyl-5-methyloxazole (38511-88-5)

Guidance literature:

With Mercury(II) toluene-p-sulphonate; for 0.0333333h; microwave irradiation;

DOI:10.1016/S0040-4039(00)00929-1

Reference yield: 85.0%

benzamide (55-21-0,27208-38-4) + 1-phenyl-propan-1-one (93-55-0) → 2,4-diphenyl-5-methyloxazole (38511-88-5)

Guidance literature:

1-phenyl-propan-1-one; With hydroxy(phenyl)-λ³-iodanyl 2,4-dinitrobenzenesulfonate; for 0.0111111h; microwave irradiation;

benzamide; for 0.0333333h; microwave irradiation;

DOI:10.1016/S0040-4039(02)02493-0

upstream raw materials:

2,4-diphenyl-1,3-oxazole

methyl iodide

benzonitrile

1-phenyl-propan-1-one

Downstream raw materials:

1-Benzoylamino-2-methyl-1-phenylethylen

benzoic acid

benzonitrile