1-Pyrrolidinecarboxylic acid, 2-[cyano[(phenylmethyl)amino]methyl]-4-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester, (2S,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[cyano[(phenylmethyl)amino]methyl]-4-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester, (2S,4R)-
CAS No.:385440-71-1
Molecular Formula:C25H31N3O5S
Molecular Weight:485.604
Hs Code.:
Mol file:385440-71-1.mol

1-Pyrrolidinecarboxylic acid,
2-[cyano[(phenylmethyl)amino]methyl]-4-[[(4-methylphenyl)sulfonyl]oxy]-,
1,1-dimethylethyl ester, (2S,4R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[cyano[(phenylmethyl)amino]methyl]-4-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester, (2S,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[cyano[(phenylmethyl)amino]methyl]-4-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester, (2S,4R)-

There total 7 articles about 1-Pyrrolidinecarboxylic acid, 2-[cyano[(phenylmethyl)amino]methyl]-4-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-37-8
oxalyl dichloride

: 2942-58-7
diethyl cyanophosphonate

: 100-46-9
benzylamine

: 385440-93-7
(2S-trans)-2-hydroxymethyl-4-[[(4-methylphenyl)sulfonyl]oxy]-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester

: 385440-71-1
(2S-trans)-2-[cyano[(phenylmethyl)amino]methyl]-4-[[(4-methylphenyl)-sulfonyl]oxy]-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 385440-71-1
(2S-trans)-2-[cyano[(phenylmethyl)amino]methyl]-4-[[(4-methylphenyl)-sulfonyl]oxy]-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / pyridine / CH₂Cl₂

2: 100 percent / LiBH₄ / tetrahydrofuran / 22 °C

3: (COCl)2; DMSO; TEA / CH₂Cl₂ / -78 - 0 °C

4: CH₂Cl₂

With pyridine; lithium borohydride; oxalyl dichloride; TEA; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 3: Swern oxidation;
DOI:10.1016/j.bmcl.2004.09.049

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 385440-71-1
(2S-trans)-2-[cyano[(phenylmethyl)amino]methyl]-4-[[(4-methylphenyl)-sulfonyl]oxy]-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / pyridine / CH₂Cl₂

2: 100 percent / LiBH₄ / tetrahydrofuran / 22 °C

3: (COCl)2; DMSO; TEA / CH₂Cl₂ / -78 - 0 °C

4: CH₂Cl₂

With pyridine; lithium borohydride; oxalyl dichloride; TEA; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 3: Swern oxidation;
DOI:10.1016/j.bmcl.2004.09.049