1H-Benzimidazole,2-(2-thienyl)-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole,2-(2-thienyl)-(9CI)
• CAS No.: 3878-18-0
• Molecular Formula: C11H8N2S
• Molecular Weight: 200.264
• Hs Code.: 2934999090
• Mol file: 3878-18-0.mol

Synonyms:2-(thien-2-yl)-1H-benzimidazole;2-(2-thiophenyl)benzimidazole;2-(2-thienyl)-1H-benzimidazole;2-Thiophen-2-yl-1H-benzoimidazole;2-thiophen-2-ylbenzimidazole;2-(thiophen-2-yl)-1H-benzimidazole;2-(thiophen-2-yl)-1H-benzo[d]imidazole;2-benzimidazol-2-ylthiophene;2-(Thiophen-2-yl)benzimidazole;

Chemical Property of 1H-Benzimidazole,2-(2-thienyl)-(9CI)

Chemical Property:

• Melting Point: 230℃
• Boiling Point: 412.2±37.0 °C(Predicted)
• PKA: 11.11±0.10(Predicted)
• PSA: 56.92000
• Density: 1.336±0.06 g/cm3(Predicted)
• LogP: 3.29140

Purity/Quality:

98% ^*data from raw suppliers

2-(2-Thienyl)-1H-benzimidazole 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole,2-(2-thienyl)-(9CI)

There total 58 articles about 1H-Benzimidazole,2-(2-thienyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

thiophene-2-carbaldehyde (98-03-3) + 1,2-diamino-benzene (95-54-5) → 2-(2-thienyl)-1H-benzimidazole (3878-18-0)

Guidance literature:

With sodium metabisulfite; In N,N-dimethyl-formamide; at 80 ℃; for 0.4h; Microwave irradiation;

DOI:10.1002/jhet.1058

Reference yield: 98.0%

thiophene-2-carbaldehyde (98-03-3) + 2-nitro-aniline (88-74-4) → 2-(2-thienyl)-1H-benzimidazole (3878-18-0)

Guidance literature:

With hydrogen; In ethyl acetate; at 60 ℃; for 20h; under 7500.75 Torr; Autoclave; Green chemistry;

DOI:10.1002/cssc.202002344

Reference yield: 98.0%

thiophene-2-carbaldehyde (98-03-3) + 1,2-Dinitrobenzene (528-29-0) → 2-(2-thienyl)-1H-benzimidazole (3878-18-0)

Guidance literature:

With hydrogen; In ethyl acetate; at 70 ℃; for 20h; under 7500.75 Torr; Autoclave; Green chemistry;

DOI:10.1002/cssc.202002344

upstream raw materials:

thiophene-2-carbaldehyde

1,2-diamino-benzene

3-(2'-thienyl)acrylophenone

(E)-1-phenyl-3-(thiophen-2-yl)-2-propen-1-one

Downstream raw materials:

5-phenylbenzo[4,5]imidazo[1,2-a]thieno[2,3-c]pyridine

C₃₃H₄₂N₄O₃S₃

C₃₂H₄₀N₄O₃S₃

C₃₁H₃₈N₄O₃S₃