(1S,2S)-[3-Chloro-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (1S,2S)-[3-Chloro-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester
• CAS No.: 388072-80-8
• Molecular Formula: C15H20ClF2NO3
• Molecular Weight: 335.779
• Mol file: 388072-80-8.mol

Synonyms:tert-butyl (1S,2S)-3-chloro-1-(3,5-diflurorbenzyl)-2-hydroxypropylcarbamate;tert-butyl (1S,2S)-3-chloro-1-(3,5-difluorobenzyl)-2-hydroxypropylcarbamate;

Chemical Property of (1S,2S)-[3-Chloro-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

Chemical Property:

• PSA: 58.56000
• LogP: 3.39120

Purity/Quality:

97% ^*data from raw suppliers

(1S,2S)-[3-Chloro-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-carbamicacidtert-butylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,2S)-[3-Chloro-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

There total 1 articles about (1S,2S)-[3-Chloro-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

[(S)-1-(3,5-difluorobenzyl)-3-chloro-2-oxo-propyl]-carbamic acid t-butyl ester (388072-77-3) → [(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-chloro-propyl]carbamic acid t-butyl ester (388072-80-8)

Guidance literature:

[(S)-1-(3,5-difluorobenzyl)-3-chloro-2-oxo-propyl]-carbamic acid t-butyl ester; With sodium tetrahydroborate; In methanol; at 20 ℃; for 12h;

With hydrogenchloride; water; In methanol; for 0.5h;

Reference yield: 90.0%

[(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-chloro-propyl]carbamic acid t-butyl ester (388072-80-8) → tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate (388071-27-0)

Guidance literature:

With potassium hydroxide; In ethanol; at 0 ℃; for 2h;

Reference yield:

[(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-chloro-propyl]carbamic acid t-butyl ester (388072-80-8) + methanesulfonyl chloride (124-63-0) → C16H22ClF2NO5S (664372-70-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

[(S)-1-(3,5-difluorobenzyl)-3-chloro-2-oxo-propyl]-carbamic acid t-butyl ester

Downstream raw materials:

C₁₆H₂₂ClF₂NO₅S

tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate

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