Carbamic acid, [[2,3-dihydro-5-[[[6-methyl-4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl ]amino]-1H-inden-2-yl]methyl]-, methyl ester

Base Information

Chemical Name:Carbamic acid, [[2,3-dihydro-5-[[[6-methyl-4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl ]amino]-1H-inden-2-yl]methyl]-, methyl ester
CAS No.:391655-29-1
Molecular Formula:C27H25F3N2O3
Molecular Weight:482.502
Hs Code.:
Mol file:391655-29-1.mol

Synonyms:

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Chemical Property of Carbamic acid, [[2,3-dihydro-5-[[[6-methyl-4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl ]amino]-1H-inden-2-yl]methyl]-, methyl ester

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Technology Process of Carbamic acid, [[2,3-dihydro-5-[[[6-methyl-4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl ]amino]-1H-inden-2-yl]methyl]-, methyl ester

There total 9 articles about Carbamic acid, [[2,3-dihydro-5-[[[6-methyl-4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl ]amino]-1H-inden-2-yl]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 391655-61-1
carbamic acid, [(5-amino-2,3-dihydro-1H-inden-2-yl)methyl]-, methyl ester

: 256397-64-5
[6-METHYL-4'-(TRIFLUOROMETHYL)-[1, 1'-BIPHENYL]-2-CARBONYL]

: 391655-29-1
{5-[(6-methyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-ylmethyl}-carbamic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/jm010294e

Reference yield:

: 4254-29-9
indan-2-ol

: 391655-29-1
{5-[(6-methyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-ylmethyl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / iPr₂NEt; DMAP / CH₂Cl₂ / 16.5 h

2: 49 percent / dimethylformamide / 3 h / 90 °C

3: 93 percent / LiAlH₄ / diethyl ether / 3 h

4: 71 percent / iPr₂NEt / CH₂Cl₂ / 1 h

5: 98 percent / fuming HNO₃; CF₃COOH / 3 h / 0 °C

6: 82 percent / H₂ / 10percent Pd/C / ethyl acetate / 16 h / 20 °C / 2585.81 Torr

7: 90 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; dmap; lithium aluminium tetrahydride; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10percent Pd/C; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm010294e

Reference yield:

: 777-72-0
methansulfonic acid 2,3-dihydro-1H-inden-2-yl ester

: 391655-29-1
{5-[(6-methyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-ylmethyl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 49 percent / dimethylformamide / 3 h / 90 °C

2: 93 percent / LiAlH₄ / diethyl ether / 3 h

3: 71 percent / iPr₂NEt / CH₂Cl₂ / 1 h

4: 98 percent / fuming HNO₃; CF₃COOH / 3 h / 0 °C

5: 82 percent / H₂ / 10percent Pd/C / ethyl acetate / 16 h / 20 °C / 2585.81 Torr

6: 90 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10percent Pd/C; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm010294e