3-tert-butylsulfanyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid

Base Information

Chemical Name:3-tert-butylsulfanyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
CAS No.:67436-13-9
Molecular Formula:C22H25NO4S
Molecular Weight:399.511
Hs Code.:2930 90 16
NSC Number:334299
Mol file:67436-13-9.mol

Synonyms:Fmoc-S-tert-butyl-Cys;N(alpha)-fluorenylmethyloxycarbonyl-S-tert-butylcysteine

Suppliers and Price of 3-tert-butylsulfanyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
Fmoc-S-tert-butyl-L-cysteine 97%
5g
$ 41.80

Activate Scientific
N-Fmoc-S-tert-butyl-L-cysteine 98+% ee
25 g
$ 167.00

AHH
Fmoc-Cys(tBu)-OH 98%
100g
$ 538.00

AK Scientific
Fmoc-Cys(tBu)-OH
100g
$ 401.00

AK Scientific
Fmoc-Cys(tBu)-OH
5g
$ 35.00

Alfa Aesar
N-Fmoc-S-tert-butyl-L-cysteine, 98%
5g
$ 70.50

Alfa Aesar
N-Fmoc-S-tert-butyl-L-cysteine, 98%
1g
$ 19.40

Ambeed
Fmoc-Cys(tBu)-OH 98%
5g
$ 24.00

Ambeed
Fmoc-Cys(tBu)-OH 98%
250mg
$ 8.00

Ambeed
Fmoc-Cys(tBu)-OH 98%
1g
$ 10.00

Total 88 raw suppliers

Chemical Property of 3-tert-butylsulfanyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid

Chemical Property:

Appearance/Colour:White to off white powder
Vapor Pressure:2.08E-15mmHg at 25°C
Melting Point:135-137 °C
Refractive Index:1.599
Boiling Point:603.4 °C at 760 mmHg
PKA:3.49±0.10(Predicted)
Flash Point:318.7 °C
PSA：100.93000
Density:1.237 g/cm³
LogP:4.90090
Storage Temp.:2-8°C
Water Solubility.:Soluble in water
XLogP3:4.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:399.15042945
Heavy Atom Count:28
Complexity:539

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-S-tert-butyl-L-cysteine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)(C)SCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Uses Fmoc-Cys(tBu)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Technology Process of 3-tert-butylsulfanyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid

There total 4 articles about 3-tert-butylsulfanyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 2481-09-6
S-tert-Butyl-N-acetyl-L-cysteine hydrochloride

: 67436-13-9
(R)-3-tert-Butylsulfanyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water; for 1h;

Reference yield:

: 135273-01-7
N,N'-bis[(9H-fluoren-9-ylmethoxy)carbonyl]-L-cystine

: 67436-13-9
(R)-3-tert-Butylsulfanyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; hydrogenchloride / water; ethyl acetate

2: trifluoroacetic acid / 4 h

With hydrogenchloride; trifluoroacetic acid; zinc; In water; ethyl acetate;

Reference yield:

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 67436-13-9
(R)-3-tert-Butylsulfanyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / acetone; water / 50 °C

2: zinc; hydrogenchloride / water; ethyl acetate

3: trifluoroacetic acid / 4 h

With hydrogenchloride; sodium carbonate; trifluoroacetic acid; zinc; In water; ethyl acetate; acetone;