4-(3-Fluorophenyl)pyridine

Base Information

• Chemical Name: 4-(3-Fluorophenyl)pyridine
• CAS No.: 39795-59-0
• Molecular Formula: C11H8FN
• Molecular Weight: 173.19
• DSSTox Substance ID: DTXSID901308343
• Mol file: 39795-59-0.mol

Synonyms:4-(3-fluorophenyl)pyridine;39795-59-0;SCHEMBL9387800;Pyridine, 4-(3-fluorophenyl)-;DTXSID901308343;AKOS006291704;EN300-378032

Chemical Property of 4-(3-Fluorophenyl)pyridine

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 173.064077422
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)F)C2=CC=NC=C2

Technology Process of 4-(3-Fluorophenyl)pyridine

There total 3 articles about 4-(3-Fluorophenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3-fluorophenyl)nicotinic acid → 4-(m-fluorophenyl)pyridine (39795-59-0)

Guidance literature:

4-(3-fluorophenyl)nicotinic acid; With trifluorormethanesulfonic acid; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Molecular sieve;

With copper(I) oxide; 1,10-Phenanthroline; In N,N-dimethyl-formamide; at 145 ℃; for 24h; Molecular sieve; Inert atmosphere; Microwave irradiation;

DOI:10.1021/acs.orglett.6b03085

Reference yield:

pyridine (110-86-1) + 3-fluorobenzenediazonium tetrafluoroborate (1996-38-9) → 2-(3-fluorophenyl)pyridine (58861-54-4) + 3-(m-fluorophenyl)pyridine (79412-32-1) + 4-(m-fluorophenyl)pyridine (39795-59-0)

Guidance literature:

With potassium acetate; 18-crown-6 ether; for 1.5h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1021/jo00183a021

Reference yield:

pyridine (110-86-1) + meta-fluoroaniline (372-19-0) → 2-(3-fluorophenyl)pyridine (58861-54-4) + 3-(m-fluorophenyl)pyridine (79412-32-1) + 4-(m-fluorophenyl)pyridine (39795-59-0)

Guidance literature:

With hydrogenchloride; sodium nitrite; Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1007/BF00512817

upstream raw materials:

pyridine

meta-fluoroaniline

3-fluorobenzenediazonium tetrafluoroborate