2-(biphenyl-4-yl)acetyl chloride

Base Information

• Chemical Name: 2-(biphenyl-4-yl)acetyl chloride
• CAS No.: 39889-69-5
• Molecular Formula: C14H11ClO
• Molecular Weight: 230.694
• Mol file: 39889-69-5.mol

Synonyms:4-Biphenylacetic acid chloride;biphenylacetyl chloride;4-phenylphenylacetyl chloride;4-biphenylacetyl chloride;4-phenylphenylacetic acid chloride;biphenyl-4-ylacetic acid chloride;

Chemical Property of 2-(biphenyl-4-yl)acetyl chloride

Chemical Property:

• Melting Point: 94-95 °C
• Boiling Point: 164-166 °C(Press: 2.5 Torr)
• PSA: 17.07000
• Density: 1.176±0.06 g/cm3(Predicted)
• LogP: 3.66150

Purity/Quality:

99%, ^*data from raw suppliers

2-(Biphenyl-4-yl)acetyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-(Biphenyl-4-yl)acetyl chloride is used as a reactant in the preparation of luminescent lanthanide complexes.

Technology Process of 2-(biphenyl-4-yl)acetyl chloride

There total 5 articles about 2-(biphenyl-4-yl)acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4-biphenylyl)acetic acid (5728-52-9) → biphenyl-4-yl-acetyl chloride (39889-69-5)

Guidance literature:

With thionyl chloride; In benzene; at 78 - 80 ℃; for 2.5h;

DOI:10.14233/ajchem.2019.21579

Reference yield: 100.0%

(4-biphenylyl)acetic acid (5728-52-9) + oxalyl dichloride (79-37-8) → biphenyl-4-yl-acetyl chloride (39889-69-5)

Guidance literature:

In N-methyl-acetamide; benzene;

Reference yield:

biphenyl-4-carboxylic acid (92-92-2) → biphenyl-4-yl-acetyl chloride (39889-69-5)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / dichloromethane / 2 h / 20 °C / Cooling with ice

2: water / dichloromethane; tert-butyl methyl ether; diethylene glycol dimethyl ether / 1 h / 60 °C

3: trichlorophosphate / tert-butyl methyl ether / 2 h / 20 °C / Cooling with ice

With water; trichlorophosphate; In dichloromethane; tert-butyl methyl ether; diethylene glycol dimethyl ether;

upstream raw materials:

(4-biphenylyl)acetic acid

oxalyl dichloride

biphenyl-4-carboxylic acid

4-biphenyl-carboxylic acid chloride

Downstream raw materials:

4-Biphenylacetaldehyde

1,1-biphenyl-4-ylacetamide

6-phenyl-3,4-dihydronaphthalen-2(1H)-one

Biphenyl-4-yl-acetic acid 4-{2-[4-(2-biphenyl-4-yl-acetoxymethyl)-3,5-dioxo-piperazin-1-yl]-ethyl}-2,6-dioxo-piperazin-1-ylmethyl ester